| 引用本文: | 李文军,陈烨,李彤旻,王洋,刘忠忱,邓晶晶.藤甲酰苷缓释片的处方优化及释药机制研究[J].中国现代应用药学,2013,30(10):1081-1085. |
| LI Wenjun,CHEN Ye,LI Tongmin,WANG Yang,LIU Zhongchen,DENG Jingjing.Formulation Optimization and the Release Mechanism of Garcinia Glycosides Sustained-release Tablets[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(10):1081-1085. |
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| 摘要: |
| 目的 制备藤甲酰苷缓释片并探讨其药物释放机制。方法 以羟丙基甲基纤维素(HPMC)为缓释材料、乙基纤维素(EC)为凝胶骨架材料，以及乳糖等为填充剂制备藤甲酰苷缓释片，采用正交设计法进行处方优化。使用DDslover软件拟合释放曲线。结果 采用湿颗粒压片法制得的骨架型藤甲酰苷缓释片具有良好的缓释效果。藤甲酰苷缓释片的体外释药行为符合Higuchi 模型，是扩散和溶蚀协同作用的结果，其释药过程用 Higuchi平面扩散模式方程，相关系数r=0.999 3(1~12 h)。结论 本方法制备的藤甲酰苷缓释片符合体外释放度要求。 |
| 关键词: 藤甲酰苷 羟丙基甲基纤维素 缓释片 释药机制 |
| DOI： |
| 分类号:R 944. 9 |
| 基金项目:国家“十一五”规划“重大新药创制”重大科技专项资助项目(2009ZX09103-030)；辽宁大学“211工程”三期建设重点资助项目 |
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| Formulation Optimization and the Release Mechanism of Garcinia Glycosides Sustained-release Tablets |
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LI Wenjun, CHEN Ye, LI Tongmin, WANG Yang, LIU Zhongchen, DENG Jingjing
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School of Pharmacy, Liaoning University, Shenyang 110036, China
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| Abstract: |
| OBJECTIVE To prepare the garcinia glycosides sustained-release tablets and study drug release mechanism in vitro. METHODS Garcinia glycosides sustained-release tablets were prepared using hydroxypropylmethyl cellulose(HPMC) as gel matrix material, ethyl cellulose (EC) as skeleton material, lactose as filler and so on. The formulation was optimized using orthogonal experimental design. DDslover software was used to fitting drug release curve. RESULTS Garcinia glycosides sustained-release tablets had good sustained-release profile. The release behavior of the tablets in vitro followed Higuchi equation. It was the synergies of diffusion and dissolution and the main mechanism of drug release was diffusion for fitting well with Higuchi equation, r=0.999 3(1-12 h). CONCLUSION The garcinia glycosides sustained-release tablets prepared meet the release requirement in vitro. |
| Key words: garcinia glycosides HPMC sustained-release tablets release mechanism |
