血栓通注射液对外伤性脑梗死患者血浆NSE、S100B、MBP和GFAP浓度的影响

Effect of Xueshuantong Injection on Plasma NSE, S100B, MBP and GFAP Concentrations in Patients with Traumatic Cerebral Infarction

关键词:  血栓通  外伤性脑梗死  神经元特异性烯醇化酶  S100B  髓鞘碱性蛋白  胶质纤维酸性蛋白  脑保护作用

Key words:  Xueshuantong injection  traumatic cerebral infarction  NSE  S100B  MBP  GFAP  cerebral protective effect

摘要:

目的 研究血栓通注射液对外伤性脑梗死患者血浆脑损伤标志物NSE、S100B、MBP和GFAP浓度的影响，从而了解其促进神经功能恢复的作用。方法 80例外伤性脑梗死患者随机分为治疗组和对照组，每组40例，对照组进行常规治疗，治疗组加用血栓通注射液治疗，测定患者治疗前、治疗后第1，3，7，14天血浆NSE、S100B、MBP和GFAP浓度，观察血栓通注射液对血浆各标志物浓度的影响。结果 治疗前，治疗组和对照组血浆NSE、S100B、MBP和GFAP浓度比较差异均无统计学意义(均P>0.05)。治疗后，与对照组相比，血栓通注射液能显著降低外伤性脑梗死患者血浆NSE、S100B、MBP和GFAP浓度(均P<0.01)。结论 血栓通注射液可显著抑制外伤性脑梗死后血浆NSE、S100B、MBP和GFAP浓度的升高，具有明显的脑保护作用。

Abstract:

OBJECTIVE To study the effect of Xueshuantong injection on plasm biomarker including NSE, S100B, MBP and GFAP concentrations in patients with traumatic cerebral infarction, and thus to investigate its effect of promoting the recovery of neural function. METHODS Eighty patients with traumatic cerebral infarction were randomly divided into control group(n=40) and treatment group(n=40). Control group obtained ordinary therapy, and treatment group obtained additional Xueshuantong injection. Pre-treatment and after 1, 3, 7, and 14 d treatment, NSE, S100B, MBP and GFAP concentraions in plasma were determined. The effects of Xueshuantong injection on these plasma biomarker were investigated. RESULTS Pre-treatment, there were no statistically significant differences of NSE, S100B, MBP and GFAP concentraions in the plasma between treatment group and control groups(all P>0.05). After treatment, compared with control group, Xueshuantong injection could markedly diminish NSE, S100B, MBP and GFAP concentraions in plasma of patients with traumatic cerebral infarction (all P<0.01). CONCLUSION Xueshuantong injection can markedly inhibit the enhancement of NSE, S100B, MBP and GFAP concentraions in plasma after traumatic cerebral infarction, and possesses obvious cerebral protective effect.