维生素B12与腔隙性脑梗塞后抑郁的关联研究

Association of Vitamin B12 with Depression after Lacunar Stroke

关键词:  腔隙性脑梗塞  抑郁症  维生素B12

Key words:  lacunar stroke  depression  vitamin B12

摘要:

目的 探讨血清维生素B12与腔隙性脑梗塞后抑郁之间关系。方法 2009年6月—2012年6月腔隙性脑梗塞患者共829例，使用汉密尔顿抑郁量表将患者分为两组：无抑郁组和抑郁组，比较两组间血清维生素B12浓度和维生素B12缺乏者的比例。在抑郁组内对汉密尔顿抑郁量表评分和血清维生素B12浓度进行曲线拟合。结果 无抑郁组患者750例，血清维生素B12平均浓度为(172.5±20.4)pmol·L^-1，其中维生素B12缺乏者212例。抑郁组79例，血清维生素B12平均浓度为(139.1±18.2)pmol·L^-1，其中维生素B12缺乏者53例。两组间维生素B12浓度和缺乏比例均存在显著差异(P<0.000 1)。通过对汉密尔顿抑郁量表评分随血清维生素B12浓度变化的曲线拟合得知，倒数曲线拟合度较好。结论 腔隙性脑梗塞后抑郁与维生素B12缺乏存在相关性。

Abstract:

OBJECTIVE To explore the association of serum vitamin B12 with depression after lacunar stroke. METHODS Between June 2009 and June 2012, 829 patients with lacunar stroke, according to Hamilton depression scale score, were divided into two groups: group with depression and group without depression. The concentration of serum vitamin B12 and the ratio of vitamin B12 deficiency were compared. The relationship between Hamilton depression scale score and the concentration of serum vitamin B12 in the group with depression was analyzed by the curve-fitting method. RESULTS The group without depression contained 750 cases and the mean concentration of serum vitamin B12 of this group was (172.5±20.4)pmol·L^-1. There were 212 cases in the group without depression which were considered as vitamin B12 deficiency. The group with depression contained 79 cases and the mean concentration of serum vitamin B12 of this group was (139.1±18.2)pmol·L^-1. There were 53 cases in the group with depression which were considered as vitamin B12 deficiency. There were significant differences in the concentration of serum vitamin B12 and the ratio of vitamin B12 deficiency(P<0.000 1). Inverse curve reflected the relationship between Hamilton depression scale score and the concentration of serum vitamin B12 in the group with depression. CONCLUSION Depression after lacunar stroke is related to vitamin B12 deficiency.