五福饮对荷瘤小鼠抑瘤率和免疫调节作用的影响

Effects of Wufu Decoction on Tumor Inhibition Rate and Immune Regulation of Tumor-burdened Mice

关键词:  五福饮  调节免疫  抗肿瘤

Key words:  Wufu decoction  immune regulation  antitumor

摘要:

目的 观察五福饮对荷S180移植瘤小鼠免疫功能的影响及抑瘤作用。方法 荷瘤小鼠随机分为模型组、环磷酰胺对照组(80 mg·kg^-1)，五福饮低、中、高剂量组(分别含生药5.25，10.5，21.0 g·kg^-1，相当于人体临床用量的10，20和40倍)及正常对照组。结果 与模型组比较，五福饮高、中2个剂量组均可明显提高荷瘤小鼠ConA诱导的脾淋巴细胞转化、小鼠NK细胞活性和血清IFN-γ、TNF-α水平，差异均有统计学意义(P<0.05)。五福饮各组对S180移植瘤抑制率为11%~16%，但与模型组比较无明显差异(P＞0.05)。结论 五福饮对S180移植瘤的抑制作用不显著，但可增强荷S180移植瘤小鼠的免疫功能。

Abstract:

OBJECTIVE To observe the effects of Wufu decoction on the immune regulation and tumor inhibition rate of tumor-burdened mice. METHODS Mice were randomly divided into six groups: model group, cyclophosphamide group, low, middle and high dose of Wufu decoction groups (5.25, 10.5, 21.0 g·kg^-1, equivalent to 10, 20 and 40 times of human clinical dosage), normal control group. RESULTS High and middle dose of Wufu decoction groups could significantly increase T lymphocyte transformations capacity induced by ConA(P<0.05), improve NK cell activity(P<0.05), and raise serum IFN-γ, TNF-α level(P<0.05). The tumor inhibition rates of three Wufu decoction groups were 11%-16%, but had no obvious difference compared with model group(P>0.05). CONCLUSION Wufu decoction has no significant inhibition to S180 transplantation tumor, but can significantly improve the immunological function of tumor-burdened mice.