新型给药系统和新技术在光动力疗法中的应用

Novel drug delivery systems and preparation techniques in photodynamic therapy

关键词:  给药系统  光动力疗法  光敏剂  剂型  制剂技术

Key words:  drug delivery system  photodynamic therapy  photosensitive drug  dosage forms  preparation techniques

摘要:

目的 阐述新型给药系统和制剂新技术在改善光动力疗法(photodynamic therapy,PDT)中的应用研究进展。方法 根据文献,对脂质体、纳米粒、聚合物胶束、微粒表面修饰、微针阵列技术、电学技术、自发光技术、上转换技术等新型给药系统和制剂新技术在PDT中的研究新进展进行阐述。结果 新型给药系统和制剂新技术在较好改善多数光敏剂生理条件下呈疏水性、易聚集及对病变组织选择性不高方面具有独特优势,值得进一步研究。结论 新型给药系统和制剂新技术的开发,有希望将光敏剂传递到人体较深部位并浓集于靶组织,具有广阔的应用前景。

Abstract:

OBJECTIVE To describe the recent development of novel drug delivery systems and preparation techniques in photodynamic therapy (PDT). METHODS The novel drug delivery systems of liposome,nanoparticles, micelles, surface modification,and the preparation techniques of microneedle arrays, electroporation, self-luminescence and upconversion used in PDT were reviewed. RESULTS The novel drug delivery systems and preparation techniques mentioned above had particular advantage on overcoming the shortage of most existing photosensitizers,such as hydrophobic, aggregate easily under physiological condition,and low accumulation selectivity to diseased tissues. CONCLUSION The novel drug delivery systems and preparation techniques above were very important to the bright future of PDT since they offered the best hope for extending the reach of photosensitive drug to regions deep in the body with a relative target.