小儿健脾膏促胃肠动力作用研究

Effects of Xiaoer Jianpi Cream on Promoting Gastrointestinal Motility

关键词:  小儿健脾膏  胃肠动力  贴剂  药理作用

Key words:  Xiaoer Jianpi cream  gastrointestinal motility  patch  pharmacological effect

摘要:

目的 观察小儿健脾膏对离体豚鼠回肠和大鼠胃肌收缩、在体大鼠胃肌收缩及整体小鼠胃排空与肠推进的影响。方法 离体和在体实验中，运用生物机能实验系统检测小儿健脾膏对回肠和胃肌收缩张力的影响；整体实验中，运用称重法和标记法测定小鼠胃排空与肠推进比率。结果 离体实验中，不同剂量的小儿健脾膏均可增大豚鼠回肠和大鼠胃肌的平均收缩幅度；在体实验中，中、高剂量小儿健脾膏可显著增加大鼠胃肌的平均收缩幅度，且高剂量对大鼠胃肌的收缩与新斯的明具有协同作用；整体实验中，不同剂量的小儿健脾膏均能显著加速阿托品所致胃肠动力障碍模型小鼠的胃排空与肠推进。结论 小儿健脾膏具有促进胃肠动力的药理作用。

Abstract:

OBJECTIVE To evaluate the effects of Xiaoer Jianpi cream on the contractile activity in ileum of guinea-pig and stomach muscle of rat in vitro, and to evaluate the effects of Xiaoer Jianpi cream on the contractile activity in stomach muscle of rat in situ and on the gastric emptying and intestinal propulsion in mice. METHODS In vitro and in situ experiments, the biological functional system was used to observe the effects of Xiaoer Jianpi cream on the contraction of ileum and stomach muscle. The gastric emptying and intestinal propulsion was researched by weighting method and labeling method in vivo. RESULTS In vitro experiment, different dosages of Xiaoer Jianpi cream increased the amplitude of contraction in guinea-pig ileum and stomach muscle of rat. In situ experiment, the large dosage and medium dosage of Xiaoer Jianpi cream could increase significantly the average contractile amplitude in stomach muscle of rat. There was a synergy between the large dosage group and neostigmine. In animal experiment, different doses of Xiaoer Jianpi cream had a significantly promotion on gastric emptying and intestinal propulsion in gastrointestinal disorder mice induced by atropine. CONCLUSION Xiaoer Jianpi cream has the effects on promoting gastrointestinal motility.