肝舒胶囊治疗二甲亚硝胺致大鼠肝纤维化的疗效研究

沈海容; 吕志平<sup>*</sup>; 刘妮; 冯劲立; 张奉学; 肖会泉<sup>*</sup>

引用本文:	沈海容,吕志平,刘妮,冯劲立,张奉学,肖会泉.肝舒胶囊治疗二甲亚硝胺致大鼠肝纤维化的疗效研究[J].中国现代应用药学,2013,30(11):1157-1160.
	SHEN Hairong,LÜ Zhiping,LIU Ni,FENG Jingli,ZHANG Fengxue,XIAO Huiquan.Study on the Effect of Ganshu Capsule on Treating Liver Fibrosis in Rats Induced by Dimethylnitrosamine[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(11):1157-1160.

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肝舒胶囊治疗二甲亚硝胺致大鼠肝纤维化的疗效研究
沈海容¹, 吕志平¹, 刘妮², 冯劲立², 张奉学², 肖会泉³
1.南方医科大学中医药学院，广州 510515;2.广州中医药大学热带医学研究所，广州 510405;3.广州中医药大学第一附属医院，广州 510405

摘要:

目的研究肝舒胶囊(GSC)对二甲亚硝胺(DMN)致大鼠肝纤维化的治疗效果。方法采用DMN大鼠肝纤维化模型，研究GSC对大鼠肝脾指数、肝脏组织形态学、肝组织羟脯氨酸(Hyp)含量以及血清透明质酸(HA)、层粘连蛋白(LN)、Ⅳ胶原(Ⅳ-C)和Ⅲ型前胶原(PCⅢ)的影响。结果 GSC高、中剂量组均能显著降低大鼠肝、脾指数以及肝组织Hyp含量(P<0.01)，同时还可以降低大鼠血清HA、LN、IV-C和PCIII的水平(P<0.01)；GSC高剂量组降低肝指数的作用明显优于秋水仙碱组(P<0.01)；GSC还具有改善肝脏组织形态的作用。结论 GSC具有良好的治疗肝纤维化效果。关键词：肝纤维化；肝舒胶囊；二甲亚硝胺；疗效

关键词: 肝纤维化肝舒胶囊二甲亚硝胺疗效

DOI：

分类号:

基金项目:广东省科技计划项目(2008B030301223)

Study on the Effect of Ganshu Capsule on Treating Liver Fibrosis in Rats Induced by Dimethylnitrosamine

SHEN Hairong¹, LÜ Zhiping¹, LIU Ni², FENG Jingli², ZHANG Fengxue², XIAO Huiquan³

1.College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China;2.Tropical Medicine Institute, Guangzhou University of Traditional Chinese Medicine, Guangdong 5l0405, China;3.Hepatitis Outpatient Service in First Affiliated Hospital of Guangzhou, University of Traditional Chinese Medicine

Abstract:

OBJECTIVE To study the effect of Ganshu capsule(GSC) on treating the liver fibrosis of rats induced by dimethylnitrosamines(DMN). METHODS The animal model of liver fibrosis in rats was induced with DMN. The liver and spleen index, liver tissue morphology and hydroxyproline content were observed. And radioimmunoassay was used to detect serum hyaluronic acid(HA), laminin protein(LN), Ⅳ collagen(Ⅳ-C) and pre-collagen type Ⅲ(PCⅢ). RESULTS The high and middle dose group of GSC could not only reduce liver index, spleen index, liver hydroxyproline content significantly, but also reduce serum HA, LN, IV-C and PCIII level significantly in rats(P<0.01). And the high dose group of GSC reduced the liver index significantly better than colchicine group(P<0.01). GSC could also improve liver tissue morphology. CONCLUSION GSC has a good effect on the treatment of liver fibrosis.

Key words: liver fibrosis Ganshu capsule dimethylnitrosamines treatment