| 引用本文: | 向蓉,要林青,武新安,闵光宁.1例黏液型铜绿假单胞菌感染患者的循证治疗[J].中国现代应用药学,2013,30(11):1236-1239. |
| XIANG Rong,YAO Linqing,WU Xin’an,MIN Guangning .Evidence-based Treatment in a Case of Infection Patient Suffering from Mucoid Pseudomonas Aeruginosa[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(11):1236-1239. |
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| 摘要: |
| 目的 运用循证医学方法为1例黏液型铜绿假单胞菌感染的患者制定抗感染治疗方案。方法 根据患者的具体情况，提出所需解决的临床问题，全面检索Cochrane 图书馆、PubMed数据库、中国期刊全文数据库和万方数据库，查找大环内酯类药物应用于黏液型铜绿假单胞菌感染的相关系统评价、Meta分析、临床随机对照试验，并对所获证据进行质量评价，进而将最佳证据应用于临床实践。结果 低浓度阿奇霉素与抗铜绿假单胞菌抗菌药物联用可清除曾经受到生物膜保护的致病菌。将以上证据提供给临床并结合患者及家属意愿后应用效果良好。结论 应用循证医学的方法可以为临床提供充分的证据，帮助临床决策，为患者制定合理的治疗方案，提高患者治疗效果。 |
| 关键词: 铜绿假单胞菌 生物被膜 大环内酯 阿奇霉素 循证治疗 支气管扩张 |
| DOI： |
| 分类号:R284.1；R917.101 |
| 基金项目: |
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| Evidence-based Treatment in a Case of Infection Patient Suffering from Mucoid Pseudomonas Aeruginosa |
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XIANG Rong1, YAO Linqing1, WU Xin’an2, MIN Guangning 2
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1.Department of Pharmacy, Second Provincial People’s Hospital of Gansu, Lanzhou 730000, China;2.Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou 730000, China
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| Abstract: |
| OBJECTIVE To formulate an evidence-based treatment plan for a patient with bronchiectasis infected the mucoid Pseudomonas aeruginosa. METHODS A search was conducted in the Cochrane Library, PubMed, CNKI and Wanfang Data to obtain and evaluate the relevant systematic reviews, meta-analysis and randomized controlled and finally to apply the best evidence in clinical practice. RESULTS The pathogens once protected by the biofilm could be cleared by the low dose of azithromycin associated with anti-Pseudomonas aeruginosa antimicrobial agents. The results was good after the the plan was applied to the patient. CONCLUSION To formulate an evidence-based treament plan can improve the patient curative effect. |
| Key words: Pseudomonas aeruginosa biofilm macrocyclic lactone azithromycin evidence-based treatment bronchiectasis |
