帕瑞昔布钠在甲状腺癌功能性颈淋巴结清扫术后镇痛效果的观察

Postoperative Analgesic Effect of Parecoxib in Thyroid Cancer Functional Neck Lymph Node Dissection

关键词:  甲状腺肿瘤  颈淋巴结清扫术  帕瑞昔布钠  镇痛

Key words:  thyroid tumors  neck dissection  parecoxib  analgesic

摘要:

目的 研究帕瑞昔布钠对甲状腺癌功能性颈淋巴结清扫术患者术后镇痛效果和心理状态的影响。方法 根据美国麻醉师协会(ASA)分级，选择ASA I-II级择期全麻下行甲状腺癌功能性颈淋巴结清扫术患者34例，随机分为帕瑞昔布钠组和对照组。帕瑞昔布钠组于术毕即刻、术后12，24，36 h分别静脉注射帕瑞昔布钠40 mg；对照组在各时点给予生理盐水5 mL。分别于术后6，12，24，48 h记录视觉模拟镇痛评分(visualanaloguescale，VAS)；并利用心理学自评量表对手术前后心理状态进行评价。结果 帕瑞昔布钠组VAS于术后6，12，24 h明显低于对照组(P<0.05)；帕瑞昔布钠组术后各项心理学评估指标均明显优于对照组(P<0.05)。结论 术后应用帕瑞昔布钠镇痛效果良好，并可改善甲状腺癌功能性颈淋巴结清扫术患者术后心理应激状态。

Abstract:

OBJECTIVE To study parecoxib thyroid cancer functional neck lymph node dissection in patients with postoperative analgesic effects and psychological state. METHODS According to the American Society of Anesthesiologists (ASA) classification, ASA I-II level elective anesthesia thyroid cancer, the functional cervical lymph node dissection in 34 patients were randomly divided into parecoxib sodium group and control group. Parecoxib group after operation immediately, 12, 24, 36, respectively was intravenously given parecoxib sodium 40 mg; 5 mL saline was administered at each time point in control group. After 6, 12, 24 and 48 h, mental state of the visual analog pain score(VAS) was recorded. The psychology self-rating scale before and after surgery were evaluated. RESULTS The parecoxib group VAS in postoperative 6, 12, 24 h, were significantly lower than the control group(P<0.05); parecoxib sodium group after the psychology assessment indicators were significantly better than the control group(P<0.05). CONCLUSION Postoperative analgesic effect of parecoxib can improve thyroid cancer functional neck lymph node dissection in patients with postoperative psychological stress.