| 引用本文: | 胡正芳,柳燕,李除夕,丁菲,贾树田.南五味子软胶囊急性毒性研究[J].中国现代应用药学,2015,32(1):37-39. |
| HU Zhengfang,LIU Yan,LI Chuxi,DING Fei,JIA Shutian.Acute Toxicity of Nanwuweizi Softcapsule[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(1):37-39. |
|
| 摘要: |
| 目的 观察南五味子软胶囊对小鼠和大鼠的急性毒性，评价其安全性。方法 采用急性毒性试验方法，以1次大剂量分别给小鼠和大鼠灌胃南五味子软胶囊内容物，连续14 d观察小鼠和大鼠行为活动等指标和毒性反应程度，并在试验结束时处死动物进行剖检，以获得南五味子软胶囊初步毒性资料。结果 小鼠和大鼠均无明显行为异常和体质量变化，也未出现死亡。结论 试验设定的最大给药量对小鼠和大鼠均无明显毒性作用，为其新药研发和临床用药提供了理论依据。 |
| 关键词: 南五味子软胶囊 急性毒性 小鼠 大鼠 |
| DOI： |
| 分类号: |
| 基金项目:南京市2010年第二批科技发展计划项目(201002018) |
|
| Acute Toxicity of Nanwuweizi Softcapsule |
|
HU Zhengfang, LIU Yan, LI Chuxi, DING Fei, JIA Shutian
|
|
Nanjing Hailing R&D for TCM Pharmaceutical Technology, Nanjing 210049, China
|
| Abstract: |
| OBJECTIVE To investigate the acute toxicity of Nanwuweizi softcapsule in mice and rats and to evaluate its safety. METHODS After Nanwuweizi softcapsule was administered intragastrically for 14 days, a series of indexes: symptom, sign, diet, excrement and weight of mice and rats were observed. All mice and rats were put to death at the end of experiment and abnormalities were examined. RESULTS There was no obvious abnormal behavior and weight change for mice and rats of the 14-day feeding experiment. And none was dead. CONCLUSION Nanwuweizi softcapsule with the largest dose has no obvious toxic response to the mice and rats, providing theoretical basis for the new drug development and clinical application of Nanwuweizi softcapsule. |
| Key words: Nanwuweizi softcapsule acute toxicity mice rats |
