| 引用本文: | 朱琳娇,陈运动,吴永江.电感耦合等离子体质谱法检测明胶空心胶囊中10种元素的含量[J].中国现代应用药学,2013,30(11):1228-1232. |
| ZHU Linjiao,CHEN Yundong,WU Yongjiang .Determination of 10 Elements in Vacant Gelatin Capsules by ICP-MS[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(11):1228-1232. |
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| 摘要: |
| 目的 建立用电感耦合等离子体质谱(ICP-MS)测定明胶空心胶囊中钒、铬、锰、镍、铜、砷、锶、镉、钡、铅10种元素含量的方法。方法 微波消解法处理明胶空心胶囊，用ICP-MS同时检测明胶空心胶囊中10种元素的含量。结果 10种元素的方法检出限范围为0.011~0.203 ng·mL-1，线性关系良好(r>0.999)，回收率为85%~115%，RSD<10%。结论 本方法准确可靠、灵敏便捷，可用于明胶空心胶囊中多种元素的测定。 |
| 关键词: 明胶空心胶囊 元素分析 电感耦合等离子体质谱法 |
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| Determination of 10 Elements in Vacant Gelatin Capsules by ICP-MS |
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ZHU Linjiao1,2, CHEN Yundong2, WU Yongjiang 1
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1.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China;2.Shaoxing Institute for Food and Drug Control, Shaoxing 312071, China
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| Abstract: |
| OBJECTIVE To establish a method for the determination of 10 elements such as V, Cr, Mn, Ni, Cu, As, Sr, Cd, Ba and Pb in vacant gelatin capsules by inductively coupled plasma-mass spectrometry(ICP-MS). METHODS The samples were digested by microwave, and ten elements were determined by ICP-MS simultaneously. RESULTS The detection limit ranges of 10 hazard elements were 0.011-0.203 ng·mL-1, the method had good linear correlation(r>0.999), and the average recoveries were in the range of 85%-115% with RSD less than 10%. CONCLUSION This method is accurate, sensitive, convenient, and can be used to analyse the multi-elements in vacant gelatin capsules |
| Key words: vacant gelatin capsules elements analysis ICP-MS |
