氨氯地平致眼结膜出血2例及其原因分析

Two Cases With Conjunctival Hemorrhage Caused by Amlodipine And Reason Analysis

关键词:  氨氯地平  结膜出血 原因分析

Key words:  Amlodipine  Conjunctival Hemorrhage  Reason analysis

摘要:

目的 提请大家注意氨氯氮平的不良反应。方法 通过对典型病例的分析,及参阅有关资料,就氨氯氮平引起眼睛出血的原因进行分析和探讨。结果 氨氯氮平可引起因血管扩张导致的头晕、头痛、潮红、低血压、心动过速、外周水肿(尤其是踝部)。较少见心悸、恶心及其他胃肠不适、精神抑郁。少见心绞痛、心动过缓、直立性低血压。过敏反应可见药疹、发热、肝功能异常。动物试验有致畸性_[1]。结论 使用氨氯氮平出现患者眼睛出血,说明该药对凝血机制有一定的影响。

Abstract:

ABSTRACT: OBJECTIVE To submit everybodys to attention to the Amlodipine’s ADR. METHODS By analyzing the typical cases and combining with referring to relative literature，to go on discussing about the causes of conjunctival hemorrhage caused by Amlodipine. RESULTS: Amlodipine could cause swirl, headache, facial blushing, hypotension, tachycardia, peripheral edema by the exangia, it is rare to palpitation, nausea, and other gastrointestinal upset, mental depression. And it is seldom to angina, bradycardia, orthostatic hypotension. It is visible to drug rashes, fever, abnormal liver function for the allergic reaction, and teratogenicity in animal experiment. CONCLUSION Appearing the conjunctival hemorrhage with Amlodipine, indicates that Amlodipine have some effect about the cruor mechanism. KEY WORDS：Amlodipine; Conjunctival Hemorrhage; Reason analysis