百令胶囊对糖尿病肾病腹膜透析患者VEGF活性、炎症因子的影响

Influecnce of Bailing Capsule on the Activity of VEGF and Inflammatory Factor of The Diabetic Nephropathy Patients with Peritoneal Dialysis

关键词:  百令胶囊  腹膜透析  细胞内皮生长因子  炎症因子

Key words:  Bailing capsule  peritoneal dialysis  vascular endothelial growth factor  inflammatory fators

摘要:

目的 通过临床随机对照试验探讨腹膜透析患者应用百令胶囊后对血管内皮细胞生长因子(vascular endothelial growth factor，VEGF)、炎症因子活性的影响。方法 行持续不卧床腹膜透析一个月以上的糖尿病肾病患者52例，按随机表法分成百令组和对照组，采用ELASE法分别测试用药前及用药1个月后患者血清及透出液VEGF活性、血清炎症因子的变化。结果 百令组用药后血清及透出液VEGF活性均较用药前降低，差异有统计学意义( P <0.01)；百令组用药后炎症因子较用药前降低，差异有统计学意义( P <0.05)；百令组用药后血清及透出液VEGF活性较对照组降低，差异有统计学意义( P <0.01)。结论 百令胶囊能降低腹膜透析患者血清及透出液中VEGF活性及炎症因子浓度，并可改善微炎症状态。

Abstract:

OBJECTIVE To explore the influence of the activity of vascular endothelial cell growth factor(VEGF), and the activity of inflammatory factor through clinical randomized controlled trials on patients with peritoneal dialysis by administration of Bailing capsule. METHODS According to randomized table, 52 diabetic nephrology patients who accept continuous ambulatory peritoneal dialysis for one month or more in our hospital were divided into Bailing capsule group and control group. The variation of the activity of the VEGF, inflammatory factor in serum and in dialysate was tested by ELISA before and after administration of the drug for one month. RESULTS In Bailing capsule group, the activity of the VEGF in serum and in dialysate after administration of the drug was significantly decreased compared with that before administration( P <0.01). In Bailing capsule group, the inflammatory factor was significantly decreased( P <0.05). The activity of VEGF in serum and in dialysate of Bailing capsule group significantly decreased compared with that in the control group( P <0.01).CONCLUSION Bailing capsule can reduce VEGF activity and inflammatory factors content in serum and in dialysate of peritonel dialysis patients, and can improve slightly inflammatory state.