丹参多酚酸盐对AECOPD患者血清8-isoPG、IL-18、IL-1β影响的临床研究

Clinical Study on the effects of Salvianolate Injection on the levels of Serum 8-isoPG, IL-18, and IL-1β in Acute Exacerbated Chronic Obstructive Pulmonary Disease Patients

关键词:  慢性阻塞性肺疾病急性加重  丹参多酚酸盐  8-异前列腺素  白介素-18  白介素-1β  肺功能

Key words:  AECOPD  salvianolate injection  8-isoPG  IL-18  IL-1β  lung function

摘要:

目的 研究丹参多酚酸盐注射液对慢性阻塞性肺疾病急性加重(Acute exacerbations chronic obstructive pulmonary disease,AECOPD)患者血清8-异前列腺素(8-isoPG)、白介素-18(IL-18)、白细胞介素-1β(IL-1β)等的影响,从气道炎症和氧化应激角度初步探讨丹参多酚酸盐治疗AECOPD的可能作用机制。方法 将60例AECOPD患者随机分为治疗组30与对照组30例,两组均予以抗感染、化痰、平喘等治疗,治疗组在此基础上加用丹参多酚酸盐200mg静脉滴注,每日1次,共14天,分别在治疗前后行肺功能检查及CAT量表评分,并用ELISA法检测治疗前后血清8-isoPG、IL-18、IL-1β水平,并与30名健康体检者血清8-isoPG、IL-18、IL-1β水平进行对照。结果 治疗前两组患者血清8-isoPG、IL-18、IL-1β、第1秒用力呼气量/用力肺活量(FEV1/FVC)、FEV1占预计值%及CAT评分值均无统计学差异(P>0.05)；治疗前两组患者血清8-isoPG、IL-18、IL-1β明显高于健康对照组(P<0.01)；治疗后两组患者血清8-isoPG、IL-18、IL-1β、肺功能、CAT评分值均有所改善(P＜0.01或P＜0.05),其中治疗组治疗后血清8-isoPG、IL-18、IL-1β、CAT评分值与对照组治疗后比较差异有统计学意义(P<0.05),而治疗后两组FEV1/FVC、FEV1%差异无统计学意义(P＞0.05)。结论 丹参多酚酸盐注射液可改善AECOPD患者临床症状及降低血8-isoPG、IL-18、IL-1β水平,其作用机制可能与抑制炎症反应和减少氧化应激有关。

Abstract:

Objective To investigate the effect of salvianolate injection on the levels of serum 8-isoPG, IL-18 and IL-1βin Acute Exacerbated Chronic Obstructive Pulmonary Disease(AECOPD) patients. Methods Sixty patients with acute exacerbated COPD were randomly assigned to the treatment group and the control group. Routine therapies for COPD were given to patients in the control group, while 20mg salvianolate injection was given to those in the treatment group by intravenous dripping, once daily for total 14 days. The changes of 8-isoPG,IL-18, IL-1β,the pulmonary functions and CAT scores were evaluated before treatment and after treatment,which is compared with those of 30 normal controls. Result There are no significant differences in the value of 8-isoPG,IL-18,IL-1β,FEV1/FVC and FEV1% before treatment between two group(P>0.05).Compared with the blank control group, the levels of serum 8-isoPG,IL-18, IL-1βand CAT scores in patient with AECOPD were increased significantly(P <0.01).The levels of serum 8-isoPG,IL-18, IL-1βand CAT scores after treatment was significantly lower than that before treatment(P <0.01);what’s more, the levels of 8-isoPG,IL-18, IL-1βand CAT scoresdecreased more significantly in the treatment group after treatment (P<0.05).The FEV1% and FEV1/FVC were significantly improved after treatment in two group(P<0.01). There are no significant differences between two group in the levels of FEV1% and FEV1/FVC (P＞0.05). Conclusions Salvianolate injection reduce the levels of 8-isoPG,IL-18and IL-1β and improve the clinical symptoms in acute exacerbate COPD patients by inhibiting inflammatory reaction and reduce the oxidative stress.