| 引用本文: | 赵惠,王明智,罗晓星,薛小燕.树枝状大分子的抗菌作用研究进展[J].中国现代应用药学,2014,31(6):767-776. |
| ZHAO Hui,WANG Mingzhi,LUO Xiaoxing,XUE Xiaoyan.Advance in Research of the Antibacterial Effect of Dendrimers[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(6):767-776. |
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| 摘要: |
| 目的 对各种树枝状大分子抗菌效能及其毒性的研究进展进行总结，为该类物质的进一步开发及应用提供参考。方法 查阅国内外相关文献，进行分析、归纳和综述。结果 具有抗菌活性的树枝状大分子主要包括糖、阳离子、肽、阴离子类及聚酰胺-胺类等树枝状大分子，上述大分子抗菌谱广，活性高，不容易诱导细菌耐药且生物相容性较好。 结论 树枝状大分子是一类潜在的抗菌候选分子及抗菌涂层材料，有良好的应用前景。 |
| 关键词: 树枝状大分子 抗菌活性 毒性 |
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| Advance in Research of the Antibacterial Effect of Dendrimers |
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ZHAO Hui1, WANG Mingzhi1, LUO Xiaoxing2, XUE Xiaoyan2
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1.The Fourth Military Medical University, School of Pharmacy, Student Company, Xi’an 710032, China;2.The Fourth Military Medical University, School of Pharmacy, Department of Pharmacology, Xi’an 710032, China
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| Abstract: |
| OBJECTIVE The research progress of antibacterial activity and toxicity for all kinds of dendrimers were summarized to provide a reference for further development and application of this kind of material. METHODS Literatures related with antibacterial effect of dendrimers from all over the world, were collected, analyzed and summarized. RESULTS Many classes of dendrimers, including glycodendrimers, cationic dendrimers, petide-based dendrimers and anionic dendrimers, show strong antimicrobial activity with wide antimicrobial spectrum, which also have good biocompatibility and do not induce bacteria resistance easily compared with traditional antibiotics. CONCLUSION Dendrimers is a potential kind of antibacterial candidates which can be used as antibacterial agents and coating materials with a broad application prospect. |
| Key words: dendrimers antibacterial activity toxicity |
