| 引用本文: | 钦富华,黄孝闻,夏晓静,吴人杰,王明军.银杏叶提取物-蒺藜总皂苷缓释微丸的制备研究[J].中国现代应用药学,2014,31(2):178-182. |
| QIN Fuhua,HUANG Xiaowen,XIA Xiaojing,WU Renjie,WANG Mingjun.Study on Preparation of Ginkgo Biloba Extract and Gross Saponin from Tribulus Terrastris Sustained Release Pellets[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(2):178-182. |
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| 摘要: |
| 目的 制备银杏叶提取物-蒺藜总皂苷(GBE-GSTT)缓释微丸。方法 采用挤出制粒滚圆法制备素丸，以微球圆整度、堆密度、脆碎度和收率为指标，通过正交试验选出优化处方工艺，用乙基纤维素进行缓释包衣。结果 缓释包衣微丸在1 h释放量约为20%，无明显突释现象；4 h释放量约为55%，8 h可达80%以上，基本符合中国药典对缓释制剂的要求。微丸体外释放符合一级动力学模型。结论 本工艺制备GBE-GSTT缓释微丸可行，操作简便，质量稳定。 |
| 关键词: 银杏叶提取物 蒺藜总皂苷 微丸 缓释 |
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| 基金项目:宁波市工业科研攻关项目(2007B10013)；浙江省大学生科技创新计划项目(2010R433001) |
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| Study on Preparation of Ginkgo Biloba Extract and Gross Saponin from Tribulus Terrastris Sustained Release Pellets |
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QIN Fuhua1, HUANG Xiaowen2, XIA Xiaojing1, WU Renjie2, WANG Mingjun1
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1.Zhejiang Pharmaceutical College, Ningbo 315100, China;2.Zhejiang Academy of Traditional Chinese Medicine, Hangzhou 310007, China
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| Abstract: |
| OBJECTIVE To prepare Ginkgo biloba extract and gross saponin from Tribulus terrastris(GBE-GSTT) sustained release pellets. METHODS Pellets were prepared by granulating extrusion spheronization method, and were further coated with ethyl cellulose. Degree of circularity, bulk density, friability and yield were selected as indicators to optimize the formulation and process by orthogonal test. RESULTS The pellets basically met the requirements of Pharmacopoeia of sustained-release preparations with the release profile of 20% at 1 h, 55% at 4 h and above 80% at 8 h respectively. The in vitro release of pellets fit the first-order kinetic model. CONCLUSION The process is feasible, simple and stable. |
| Key words: Ginkgo biloba extract gross saponin from Tribulus terrastris pellets sustained release |
