乌灵菌粉对实验性动脉粥样硬化兔的抗氧化系统及炎症因子的影响

Effects of Xylaria Nigripes Powder on Antioxidant System and Inflammation Factor in Experimental Atherosclerosis Rabbits

关键词:  乌灵菌粉  兔动脉粥样硬化  抗氧化系统  炎症因子

Key words:  Xylaria nigripes powder  atherosclerosis  antioxidant system  inflammation factor

摘要:

目的 探讨乌灵菌粉对实验性动脉粥样硬化兔的抗氧化系统及炎症因子的影响。方法 建立兔的动脉粥样硬化模型，同时连续给予乌灵菌粉(100 mg·kg^-1·d^-1)12周，测定兔血浆中总胆固醇、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙二醛(MDA)、C反应蛋白(CRP)，白介素6，肿瘤坏死因子含量及超氧化物歧化酶(SOD)，谷胱甘肽过氧化物酶(GSH-Px)活力，并观察主动脉病理学形态改变。结果 给予乌灵菌粉可有效减小高脂饲料引起兔动脉粥样硬化斑块的厚度，同时使动脉粥样硬化兔血浆TG、MDA、CRP含量显著下降(P<0.01)，HDL-C含量、SOD及GSH-Px活力显著升高(P<0.01)。结论 乌灵菌粉能降低动脉粥样硬化兔TG水平及增加抗氧化酶活力，抑制部分炎性因子的产生来达到降低或缓解动脉粥样硬化的目的。

Abstract:

OBJECTIVE To observe the effects of Xylaria nigripes powder on antioxidant system and inflammation factor in experimental atherosclerosis rabbits. METHODS Atherosclerosis rabbits model were established, simultaneously continuously gives Xylaria nigripes powder 100 mg·kg^-1·d^-1 12 weeks, measured rabbit plasma total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), malondialdehyde (MDA), C-reactiveprotein (CRP), interleukin 6(IL-6), tumor necrosis factor-α(TNF-α) content, and the activities of superoxide dismutase(SOD) and gutathione peroxidase (GSH-Px). The pathomorphological changes of aorta were observed. RESULTS Administration of Xylaria nigripes powder could effectively reduce the thick of atherosclerotic plaques and decrease plasma content of TG, MDA and CRP (P<0.01), while rise the content of HDL-C and activities of SOD and GSH-Px(P<0.01). CONCLUSION Xylaria nigripes powder reduces the level of TG, increase the activities of antioxidant and inhibit the production of part inflammatory factor to reduce atherosclerosis.