| 引用本文: | 杨念云,刘培,郭建明.连钱草提取物对肾结石模型大鼠的防治作用[J].中国现代应用药学,2014,31(8):918-920. |
| YANG Nianyun,LIU Pei,GUO Jianming.Preventive Effects of Glechoma Longituba Extract on Experimental Renal Calculus in Rats[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(8):918-920. |
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| 摘要: |
| 目的 观察连钱草提取物对肾结石模型大鼠的防治作用。方法 大鼠饲饮含乙二醇和氯化铵的水建立肾结石模型，测定给药后各组大鼠24 h排尿量，血清钙的含量，以及肾组织钙和草酸的含量。观察肾组织病理学变化。结果 连钱草提取物可显著增加肾结石大鼠24 h排尿量，明显降低肾组织草酸含量，以及血清和肾组织中钙含量，减少草酸钙结晶在肾组织中的沉积。结论 连钱草提取物可以增加尿量，降低血清及肾组织中钙含量；减轻大鼠肾组织因结石引起的损伤和病变，减少肾内草酸钙结晶，从而防治肾结石。 |
| 关键词: 连钱草 肾结石 草酸钙 |
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| 基金项目:江苏高校优势学科建设工程资助项目(ysxk-2010)；南京中医药大学中药学一级学科开放课题资助项目(2011ZYX1-001) |
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| Preventive Effects of Glechoma Longituba Extract on Experimental Renal Calculus in Rats |
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YANG Nianyun, LIU Pei, GUO Jianming
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Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China
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| Abstract: |
| OBJECTIVE To investigate the preventive effects of Glechoma longituba extract on experimental renal calculus in rats, and explore its mechanism. METHODS The rat model of renal calcium oxalate stones was induced by administrating ethylene glycol and ammonia chloride. The 24 h urinary output coefficient and histopathological status of kidneys, the serum calcium levels, the renal tissue calcium and oxalic acid contents were detected. RESULTS G. longituba extract could markedly increase the 24 h urinary outputs and decrease the calcium oxalate deposits in the kidneys and the pathological change degrees of the kidneys. The serum calcium levels were decreased significantly. The renal tissue calcium and oxalic acid contents were decreased significantly. CONCLUSION G. longituba extract can increase the urinary output, improve the elimination and metabolism of Ca2+ in the blood and kidneys, decrease the damage caused by the renal stone, and obviously inhibit the formation of the kidney calcium oxalate stone in rats. |
| Key words: Glechoma longituba renal calculus calcium oxalate |
