三七叶总皂苷对高脂血症大鼠血脂、肝功能及脂质过氧化的影响

Effect of the Total Saponins of Panax Notoginseng Leaves on Blood Lipid Levels, Liver Function and Lipid Peroxidation in Hyperlipidemia Rats by Fat Emulsion

关键词:  三七叶总皂苷  高脂血症  血脂  脂质过氧化

Key words:  total saponins of Panax notoginseng leaves  hyperlipidemia  blood lipid  lipid peroxidation

摘要:

目的 探讨三七叶总皂苷对实验性高脂血症大鼠血脂水平、肝功能及脂质过氧化的影响。方法 采用SD大鼠灌胃脂肪乳剂建立高脂血症模型，给予三七叶总皂苷4周，检测血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)；在给予三七叶总皂苷10周后，检测血清和肝组织中超氧化物歧化酶(SOD)、丙二醛(MDA)。结果 三七叶总皂苷可降低大鼠血清TC、LDL-c、ALT、AST，升高HDL-c/TC比值；同时能提高血清和肝组织中SOD的活力，降低MDA水平。结论 三七叶总皂苷可以调节高脂血症模型大鼠血脂水平和肝功能，同时具有一定的抵抗脂质过氧化作用，提示三七叶总皂苷对预防高胆固醇血症具有积极作用。

Abstract:

OBJECTIVE To investigate the effect of the total saponins of Panax notoginseng leaves(PnGL) on blood lipid levels, liver function and lipid peroxidation in experimental hyperlipidemia rats by fat emulsion. METHODS Spraggs Dawley rats were administered with fat emulsion to establish hyperlipidemia model. The treatment groups were simultaneously administered with PnGL for 4 weeks. Serum total cholesterol(TC), triglycerides(TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol(LDL-c), alanine aminotransferase(ALT), aspartate aminotransferase(AST) were detected. After giving PnGL for 10 weeks, serum and liver tissue super oxide diastase(SOD), paraformaldehyde(MDA) were determined. RESULTS Both 100 mg and 200 mg PnGL could reduce the level of the serum TC, LDL-c, ALT, AST and increase HDL-c/TC ratio in rats. Simultaneously, the two doses could increase the vitality of SOD in the serum and liver tissue, and decrease the MDA level. CONCLUSION The blood lipid levels and liver function in hyperlipidemia rat could be regulated by PnGL, and also have certain resistance of lipid peroxidation. It is indicated that PnGL plays a positive role in the prevention and treatment of hyperlipidemia.