| 引用本文: | 李会英,潘家琪,汤治元.扑热息痛肝毒性中炎症反应的研究进展[J].中国现代应用药学,2014,31(6):763-767. |
| LI Huiying,PAN Jiaqi,TANG Zhiyuan.Progress of Inflammation in Liver Toxicity Caused by Acetaminophen[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(6):763-767. |
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| 摘要: |
| 扑热息痛(N-acetyl-para-aminophenol，APAP)是临床应用最广泛的解热镇痛药；作为肝毒性工具药物，APAP也被广泛用于药物肝毒性机制研究和测试药物的护肝潜力。炎症是加重细胞损伤的一个潜在因素，也能限制细胞损伤，清除细胞碎片和促进再生。30余年来，APAP肝毒性机制的研究和讨论一直在持续。笔者针对APAP肝毒性中的细胞内事件，尤其是与炎症反应、炎症介质、炎症细胞之间的关系进行综述，为临床应用和毒性机制研究提供参考。 |
| 关键词: 扑热息痛 肝毒性 炎症 |
| DOI： |
| 分类号:R969 |
| 基金项目:国家自然科学基金项目(81273582)；宁波市自然科学基金项目(2012A610211) |
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| Progress of Inflammation in Liver Toxicity Caused by Acetaminophen |
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LI Huiying1, PAN Jiaqi2, TANG Zhiyuan2
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1.The Affiliated Hospital of Medical College of Ningbo University, Ningbo 315020, China;2.Medical School of Ningbo University, Ningbo 315211, China
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| Abstract: |
| As the most widely used antipyretic analgesic, acetaminophen has been widely used as a model drug to study mechanisms of chemical-induced liver toxicity and test hepato-protective potential of new drugs. Inflammation may aggravate cell damage, by limiting cell injury, removing cell debris and promoting regeneration. The mechanisms of AAP-induced liver cell injury have been extensively investigated and discussed for more than 30 years. This review focuses on the intracellular events of acetaminophen-induced hepatotoxicity, particularly the relevance of the inflammatory response, inflammatory mediators and inflammatory cells, to help improve clinical application and lay a good basis for mechanism investigation. |
| Key words: acetaminophen hepatotoxicity inflammation |
