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引用本文:朱海静,焦宇.Aurora激酶及其抑制剂的研究进展[J].中国现代应用药学,2014,31(10):1288-1296.
ZHU Haijing,JIAO Yu.Progress of Aurora Kinase and Its Inhibitors[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(10):1288-1296.
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Aurora激酶及其抑制剂的研究进展
朱海静1, 焦宇2
1.解放军第二炮兵总医院,北京 100088;2.中国药科大学有机化学教研室,南京 211198
摘要:
目的 从结构出发介绍Aurora激酶及其抑制剂的研究进展。方法 总结 Aurora激酶抑制剂骨架特征和结合模式,以及进入临床的Aurora激酶抑制剂的研究进展。结果和结论 Aurora激酶家族是肿瘤治疗的一个新兴靶标。腺嘌呤骨架可能是设计高活性Aurora激酶抑制剂的重要母核。
关键词:  Aurora激酶  抑制剂  结合模式  抗肿瘤
DOI:
分类号:R284.1;R917.101
基金项目:
Progress of Aurora Kinase and Its Inhibitors
ZHU Haijing1, JIAO Yu2
1.The Second Artillery General Hospital of Chinese People’s Liberation Army, Beijing 100088, China;2.Division of Organic Chemistry, China Pharmaceutical University, Nanjing 211198, China
Abstract:
OBJECTIVE To introduce the research progress of Aurora kinase and its inhibitors based on their structures. METHODS To summarize the chemical scaffold , the common binding modes, and the clinical progress of Aurora kinase inhibitors. RESULTS & CONCLUSION The Aurora kinase had emerged as an attractive target for cancer therapies. The adenosine mimic scaffolds could be used for further study to design addtional potential inhibitors of Aurora with high inhibitory activity.
Key words:  Aurora kinase  inhibitor  binding mode  anti-tumor
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