| 引用本文: | 王卫芳,王丽娅,胡璞.盐酸氯普鲁卡因的合成[J].中国现代应用药学,2015,32(3):304-306. |
| WANG Weifang,WANG Liya,HU Pu.Synthesis of Chloroprocaine Hydrochloride[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(3):304-306. |
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| 摘要: |
| 目的 合成盐酸氯普鲁卡因并改进工艺。方法 以2-氯-4-硝基苯甲酸为起始物料，经过还原、酯化、成盐3步反应制得盐酸氯普鲁卡因。结果 目标物经IR、1H-NMR、13C-NMR和MS确证结构，反应总收率达到73.9%，纯度为99.76%。结论 该合成路线操作简便、反应条件温和，适于工业化生产。 |
| 关键词: 氯普鲁卡因 2-氯-4-硝基苯甲酸 合成 |
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| Synthesis of Chloroprocaine Hydrochloride |
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WANG Weifang, WANG Liya, HU Pu
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Zhejiang Xianju Pharmaceutical Co., Ltd., Xianju 317300, China
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| Abstract: |
| OBJECTIVE To synthesis chloroprocaine hydrochloride and optimize the reaction conditions. METHODS The chloroprocaine hydrochloride was synthesized from 2-chloro-4-nitrobenzoic acid via reduction, esterification and salification. RESULTS The structure of product was identified by IR, 1H-NMR, 13C-NMR and MS, the total yield was 73.9% and the HPLC purity was 99.76%. CONCLUSION The synthetic process is simple, easy to control and suitable for industrial production. |
| Key words: chloroprocaine 2-chloro-4-nitrobenzoic acid synthesis |
