| 引用本文: | 张艳,吴永江,王龙虎,杜文俊,刘雪松.黄姜有效成分薯蓣皂素结晶工艺研究[J].中国现代应用药学,2015,32(3):301-304. |
| ZHANG Yan,WU Yongjiang,WANG Longhu,DU Wenjun,LIU Xuesong.Research on Crystallization Technique of Diosgenin[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(3):301-304. |
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| 摘要: |
| 目的 研究并确定黄姜提取液中薯蓣皂素的最佳结晶工艺参数。方法 以晶体纯度和析出率为指标，采用单因素实验法考察结晶温度、结晶时间、降温速度和搅拌速度4个因素对产品的影响。结果 最佳的工艺条件为：结晶温度为30 ℃、静置时间为2 h、降温速度为33~50 ℃?h-1、搅拌速度为60 r?min-1时，该工艺条件使产品纯度达到98% 以上，析出率为75%~80%。结论 该方法可靠、稳定，可为工业生产提供参考数据。 |
| 关键词: 黄姜 薯蓣皂素 结晶 |
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| Research on Crystallization Technique of Diosgenin |
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ZHANG Yan, WU Yongjiang, WANG Longhu, DU Wenjun, LIU Xuesong
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College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
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| Abstract: |
| OBJECTIVE To investigate the different parameters influenced on the process of crystallization of dioscorea and determine the optimal conditions. METHODS Based on the crystal purity and precipitation rate, the influences of crystallization temperature, crystallization time, cooling rate and stirring rate on product were investigated by single factor experiment. RESULTS When the crystallization temperature was 30 ℃, the holding time was 2 h, cooling rate was 33-50 ℃?h-1 and the stirring speed was 60 r?min-1, the product purity could achieve more than 98% and the precipitation rate was 75%-80%. CONCLUSION The method is reliable and stable, and can provide reference data for industrial production. |
| Key words: dioscorea diosgenin crystallization |
