| 引用本文: | 王如意,刘怡.共聚维酮对交联聚维酮改善溶出度作用的影响[J].中国现代应用药学,2015,32(1):42-45. |
| WANG Ruyi,LIU Yi.Influence of Copovidone on the Dissolution Improvement Effect of Crospovidone[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(1):42-45. |
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| 摘要: |
| 目的 考察共聚维酮对交联聚维酮改善溶出度作用的影响。方法 以头孢呋辛酯、阿苯达唑和吲哚美辛为模型药，采用直接压片工艺制备片剂，以溶出度为主要评价指标，考察交联聚维酮和共聚维酮用量对难溶性模型药物溶出度的影响。结果 共聚维酮的加入，可以在超级崩解剂交联聚维酮用量不变甚至减少的情况下，较大的提高头孢呋辛酯和阿苯达唑的溶出度，而对吲哚美辛的溶出度无显著影响。结论 共聚维酮可以显著增强交联聚维酮对某些药物溶出度的改善作用。 |
| 关键词: 交联聚维酮 共聚维酮 难溶性药物 溶出度 |
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| Influence of Copovidone on the Dissolution Improvement Effect of Crospovidone |
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WANG Ruyi, LIU Yi
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Aashland(China) Holding Co., Ltd., Shanghai 200233, China
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| Abstract: |
| OBJECTIVE To investigate the influence of copovidone on dissolution improvement of crospovidone, METHODS Cefuroxime axetil, albendazole and indomethacin were adopted as model drugs.To determine the dissolution of the drugs to explore the influence of copovidone. RESULTS Dissolution of cefuroxime axetil and albendazole could be enhanced by the addition of copovidone without changing the usage level of crospovidone, even under the condition of decreasing the concentration of crospovidone, but there was no effect on the dissolution of indomethacin. CONCLUSION Copovidone can significantly enhance the dissolution improvement effect of crospovidone on some poorly water soluble drugs. |
| Key words: crospovidone copovidone poorly water soluble drugs dissolution |
