环孢素A超说明书适应证使用情况分析

Induction and analysis of the off-label uses on indications of cyclosporine A

关键词:  环孢素A  超说明书用药  适应证  合理用药

Key words:  cyclosporine A  the off-label uses  indications  rational use of drugs

摘要:

目的 归纳并分析环孢素A在临床运用中超说明书适应证用药情况及其合理性，为临床医师治疗用药和临床药师审核用药合理性提供参考。方法 查阅药品说明书、相关文献及专业网站，并结合笔者所在医院环孢素A的使用情况进行归纳和总结。结果 环孢素A在临床使用中，多超说明书适应证用于韦格纳肉芽肿病、严重性溃疡性结肠炎、干燥综合征、重型系统性红斑狼疮、干燥性角结膜炎及相关的自身免疫性皮肤病。结论 环孢素A超适应证用药存在其合理性和可行性，但应注意其用法用量，及时根据血药浓度变化调整用量，避免严重不良反应的发生。

Abstract:

OBJECTIVE To conclude the cases of the off-label uses on indications of cyclosporine A in clinical application and analyze whether these uses were scientific and reasonable so as to provide a reference to the clinicians and the pharmacists. METHODS Referring to drug labels, relevant literatures and professional website as well as combining with the actual uses of cyclosporine A in my hospital to conclude and analyze the off-label uses of cyclosporine A. RESULTS The off-label uses on indications of cyclosporine A included Wegener granulomatosis, severe ulcerative colitis, Sjgren’s syndrome, severe systemic lupus erythematosus (SLE), keratoconjunctivitis sicca and autoimmune skin diseases. CONCLUSION The off-label uses on indications of cyclosporine A have certain reasonableness and scientificity. But we should pay attention to its usage and dosage, and adjust the dosage according to the patient’s blood concentrations in order to avoid the happening of severe adverse reactions.