| 引用本文: | 胡海红,沈水杰,曾苏.扁桃酸对映体分析方法的研究进展[J].中国现代应用药学,2015,32(4):508-513. |
| HU Haihong,SHEN Shuijie,ZENG Su.Advances in Analysis of Mandelic Acid Enantiomers[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(4):508-513. |
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| 摘要: |
| 苯乙烯广泛存在于环境中，人体少量吸入，没有毒性反应，而长期暴露于高浓度苯乙烯环境，可能引起呼吸系统等相关疾病。扁桃酸是苯乙烯的主要代谢物，是检测苯乙烯暴露水平的生物标志物。另外，扁桃酸也是重要的手性药物中间体，其光学纯度直接影响下游产品的质量，因此有必要发展快速、准确、灵敏、简便、分离性能好的药物对映体测定方法来提供中间体的质控数据。本文综述了扁桃酸对映体几种分析方法的研究进展，为建立准确、简便地检测扁桃酸对映体的分析方法提供参考。 |
| 关键词: 扁桃酸 苯乙烯 手性对映体 分离 分析 |
| DOI： |
| 分类号:R917 |
| 基金项目:国家自然科学基金(81202498)；中央高校基本科研业务费专项资金(2013QNA7016) |
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| Advances in Analysis of Mandelic Acid Enantiomers |
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HU Haihong1, SHEN Shuijie2, ZENG Su1
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1.Laboratory of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Anti-cancer Drug Research, Zhejiang University, Hangzhou 310058, China;2.Center for Developmental Therapeutics, Seattle Children’s Hospital Research Institute, Division of Gastroenterology, Department of Pediatrics, University of Washington, Seattle, Washington 98101, USA
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| Abstract: |
| Styrene widely exists in the environment. There is no toxicity when a small amount is inhaled by humans. Long-term exposure to the heaviest styrene may lead to the diseases of respiratory system. Therefore, detection of mandelic acid can provide an important basis for monitoring environmental styrene content. In addition, mandelic acid is also a vital intermediate of chiral drugs and its optical purity directly affects the quality of downstream products. Therefore, it is necessary to develop rapid, accurate, sensitive, simple, good separation methods to detect drug enantiomers. By these methods, it can obtain the quality control data. In this review, several detection methods provide valuable references for accurate and simple detection of mandelic acid enantiomers. |
| Key words: mandelic acid styrene enantiomers separation analysis |
