水杨醛缩氨基脲含硅有机锡化合物的合成和抑菌活性测试

Synthesis and Antibacterial Activity of Silicon Containing Organotin Complexes of Salicylal Dehydethiosemicarbazones

关键词:  有机锡  合成  抑菌活性

Key words:  organotin  synthesis  antibacterial activity

摘要:

目的 合成新型的含硅有机锡化合物，并进行抑菌活性测试。方法 利用4种水杨醛缩氨基脲配体与(Me₃SiCH₂)₂SnCl₂通过常温下的自组装反应合成了4种新型含硅有机锡化合物，利用红外光谱、核磁共振以及X-射线单晶衍射对所得产物的结构进行表征，通过纸片扩散法测试产物的抑菌活性。结果 在化合物1~4中，水杨醛缩氨基脲配体均呈现三齿配体形式与锡原子螯合配位，中心锡原子呈五配位的三角双锥结构。抑菌实验发现3种新合成的水杨醛缩氨基脲含硅有机锡化合物对G⁺菌包括金黄色葡萄球菌、G⁺蜡样芽孢杆菌和真菌蜡蚧轮枝孢菌显示抑菌作用。化合物3对金黄色葡萄球菌的抑菌圈为20 mm，最低抑菌浓度为25.17 mol·L^-1。此类化合物对G^-菌包括大肠杆菌、伤寒杆菌、产气肠杆菌无明显抑制作用。结论 水杨醛缩氨基脲含硅有机锡化合物对G⁺菌包括金黄色葡萄球菌及真菌蜡蚧轮枝孢菌具有一定的抑菌活性，对G^-菌无明显的抑制作用。

Abstract:

OBJECTIVE To synthesis the new organic tin compound containing silicon and to test its antibacterial activity. METHODS Four novel organotin compounds containing silicon were synthesized by reaction of corresponding salicylaldehyde semicarbazones with (Me₃SiCH₂)₂SnCl₂ at room temperature, respectively. The products were characterized by IR, NMR and X-ray diffraction. The antibacterial activity of the products were evaluated by disk diffusion method. RESULTS Salicylaldehyde semicarbazone ligands chelated the tin atom in the form of tridentate ligand, central tin atom was pentacoordinate trigonal bipyramidal structure. Antibacterial experiment showed that 3 compounds showed inhibitory effect against G⁺ bacteria: Staphylococcus aureus and Bacillus cereus G⁺ and fungus Verticillium lecanii. The antibacterial ring of compound 3 against Staphylococcus aureus was 20 mm and minimum inhibitory concentration was 25.17 mol·L^-1, furthermore the study also showed that the compounds had no inhibitory effect on G^- bacteria including Escherichia coli, typhoid bacillus and Enterobacter aerogenes. CONCLUSION salicylaldehyde semicarbazone organotin compounds containing silicon has certain antibacterial activity against G⁺ bacteria including Staphylococcus aureus and fungus Verticillium lecanii, without inhibitory effect on G^- bacteria.