| 引用本文: | 满红霞,肖培云,杨永寿,那凯歌,谭巧云.特发性肺纤维化的发病机制及药物治疗研究进展[J].中国现代应用药学,2015,32(8):1024-1028. |
| MAN Hongxia,XIAO Peiyun,YANG Yongshou,NA Kaige,TAN Qiaoyun.Pathogenesis of Idiopathic Pulmonary Fibrosis and Its Advances in Cytokine Treatment[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(8):1024-1028. |
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| 摘要: |
| 特发性肺纤维化是一种以两肺间质纤维化伴蜂窝状改变为特征的疾病，其发病率及死亡率逐年增高，且生存期较短，愈后极差，几乎与恶性肿瘤无异。因此，特发性肺纤维化发病机制和治疗也成为国际医学界的研究热点。本文就其病发机制和药物治疗研究进展进行了综述，为今后的进一步研究提供参考。 |
| 关键词: 特发性肺纤维化 发病机制 细胞因子 药物治疗 |
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| 基金项目:国家自然科学基金项目(81360634、81060329)；云南省教育厅科学研究基金项目(2011Z053)；云南省科技计划项目(2015FA025) |
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| Pathogenesis of Idiopathic Pulmonary Fibrosis and Its Advances in Cytokine Treatment |
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MAN Hongxia1, XIAO Peiyun1, YANG Yongshou2, NA Kaige1, TAN Qiaoyun1
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1.College of Pharmacy and Chemistry, Dali University, Dali 671000, China;2.Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali 671000, China
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| Abstract: |
| Idiopathic pulmonary fibrosis is a kind of two pulmonary fibrosis disease characterized with honeycomb change, its incidence and mortality rate increased year by year, and lifetime is short, the poor prognosis is almost the same with malignant tumor. Therefore, pathogenesis and treatment of idiopathic pulmonary fibrosis has become the focus in the international medical community. The paper reviewed the disease mechanism and drug treatment research progress, to provide a reference for the further research. |
| Key words: idiopathic pulmonary fibrosis pathogenesis cytokines clinical medication |
