| 引用本文: | 林薇,姚静,周建平.川陈皮素自组装前体脂质体大鼠在体肠吸收研究[J].中国现代应用药学,2015,32(7):817-820. |
| LIN Wei,YAO Jing,ZHOU Jianping.Intestinal Absorption Kinetics of Nobiletin Self-assemble Proliposomes in Rats[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(7):817-820. |
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| 摘要: |
| 目的 考察川陈皮素自组装前体脂质体在大鼠肠道的吸收情况。方法 以川陈皮素溶液、普通脂质体为对照，采用单向灌流法，研究不同肠段川陈皮素自组装前体脂质体的大鼠肠道吸收动力学。结果 3种制剂在全肠段都有吸收，在各个肠段，3种制剂的净累积吸收量、Ka和Peff均表现为川陈皮素自组装前体脂质体>川陈皮素普通脂质体>川陈皮素(P<0.05)。结论 川陈皮素自组装前体脂质体可显著促进川陈皮素的口服吸收。 |
| 关键词: 川陈皮素 自组装前体脂质体 肠道吸收 |
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| Intestinal Absorption Kinetics of Nobiletin Self-assemble Proliposomes in Rats |
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LIN Wei1, YAO Jing2, ZHOU Jianping2
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1.Department of Pharmacy, The Affiliated Hospital of Medical College, Ningbo University, Ningbo 315020, China;2.Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
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| Abstract: |
| OBJECTIVE To investigate the intestinal absorption kinetics of nobiletin self-assemble proliposomes(NSAP) in rats. METHODS Compared with nobiletin and nobiletin liposome, the in situ intestinal absorption of NSAP in different intestinal segments was investigated by means of single-pass rat intestinal perfusion technique. RESULTS The results showed that three preparations could be absorbed at each intestinal segment. The cumulative absorptions, Ka and Peff of three preparations at each intestinal segment appeared NSAP>nobiletin liposome>nobiletin(P<0.05). CONCLUSION NSAP can effectively improve the oral absorption of nobiletin in the intestinal tract. |
| Key words: nobiletin self-assemble proliposome intestinal absorption |
