| 引用本文: | 黎雪清,张力扬,殷果,杨敏,郑党儿.四苯硼钠滴定液浓度测量的不确定度评定[J].中国现代应用药学,2015,32(8):983-986. |
| LI Xueqing,ZHANG Liyang,YIN Guo,YANG Min,ZHENG Dang’er.Evaluation of Uncertainty for Concentration Calibration of (C6H5)4BNa Titration Solution[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(8):983-986. |
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| 四苯硼钠滴定液浓度测量的不确定度评定 |
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黎雪清1,2, 张力扬1,2, 殷果1,2, 杨敏1,2, 郑党儿3
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1.深圳市药品检验所，深圳 518057;2.深圳药品质量标准研究重点实验室，深圳 518057;3.广州铁路集团公司中心计量所，广州 510080
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| 摘要: |
| 目的 对按中国药典2010年版第一增补本方法配制和标定的四苯硼钠滴定液(0.02 mol·L-1)浓度进行不确定度评定。方法 通过对不确定度来源分析，建立测量模型，对标定过程中各不确定度的分量进行分析评估。结果 通过计算各变量的不确定度分量，得到本次标定浓度的相对标准不确定度为4.46×10-3，合成标准不确定度为8.9×10-5 mol·L-1，扩展不确定度U=0.000 18 mol·L-1，k=2。结论 建立了四苯硼钠滴定液浓度的测量不确定度评定方法，通过分析评估各分量不确定度的大小而明确测量不确定度的主要因素，优化实验条件使测定结果更加可靠准确。 |
| 关键词: 四苯硼钠滴定液 不确定度 评定 |
| DOI： |
| 分类号:R927.11 |
| 基金项目: |
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| Evaluation of Uncertainty for Concentration Calibration of (C6H5)4BNa Titration Solution |
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LI Xueqing1,2, ZHANG Liyang1,2, YIN Guo1,2, YANG Min1,2, ZHENG Dang’er3
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1.Shenzhen Institute for Drug Control, Shenzhen 518057, China;2.Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen 518057, China;3.Guangzhou Railway Group Company Center Measurement, Guangzhou 510080, China
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| Abstract: |
| OBJECTIVE To evaluate for the uncertainty of the concentration of (C6H5)4BNa (0.02 mol·L-1) titration solution prepared and calibrated according to the method in the Chinese Pharmacopoeia first addition of the 2010 edition. METHODS According to the sources of uncertainty analysis, the measurement model was established and the various influencing factors in the calibration process was evaluated. RESULTS By calculating each fraction of uncertainty in various variable parameters, the relative standard uncertainty was 4.46×10-3, the combined uncertainty was 8.9×10-5, and the expanded uncertainty was 0.000 18 mol·L-1, k=2. CONCLUSION The method of the uncertainty evaluation for calibrating the concentration of (C6H5)4BNa titration solution is established. The more reliable results of the measurement could be obtained when the measure was optimized by magnitude analysis all uncertainty. |
| Key words: (C6H5)4BNa titration solution uncertainty evaluate |
