UPLC-Q-TOF-MS测定保健食品中非法添加的未知西地那非类物质

裘一婧; 邹耀华

引用本文:	裘一婧,邹耀华.UPLC-Q-TOF-MS测定保健食品中非法添加的未知西地那非类物质[J].中国现代应用药学,2015,32(8):1000-1004.
	QIU Yijin,ZOU Yaohua.Determination of Illegal Added Unknown Sildenafil Substances in Health Care Products by UPLC-Q-TOF-MS[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(8):1000-1004.

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UPLC-Q-TOF-MS测定保健食品中非法添加的未知西地那非类物质
裘一婧, 邹耀华
杭州市食品药品检验研究院，杭州 310015

摘要:

目的建立超高效液相色谱四级杆飞行时间串联质谱法测定保健食品中非法添加的西地那非类成分。方法采用ZORBAX SB C₁₈色谱柱(4.6 mm×150 mm，5 μm)，流动相：乙腈(A)-0.1%甲酸水溶液(B)，梯度洗脱，采用TOF-MS/MS扫描模式检测。结果样品中检测出西地那非类未知化合物，经MSC与Chemispider分析，分式子为C₂₄H₃₄N₆O₄S₂。结论该方法可以用于快速检测保健食品中非法添加的未知西地那非类物质。

关键词: 超高效液相色谱四级杆飞行时间串联质谱保健食品非法添加西地那非类物质

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Determination of Illegal Added Unknown Sildenafil Substances in Health Care Products by UPLC-Q-TOF-MS

QIU Yijin, ZOU Yaohua

Hangzhou Institute for Food and Drug Control, Hangzhou 310015, China

Abstract:

OBJECTIVE To establish a UPLC/Q-TOF-MS method for the detection of illegal added unknown sildenafil substances in health care products. METHODS ZORBAX SB C₁₈ chromatographic column(4.6 mm×150 mm, 5 μm) was used. Mobile phase was acetonitrile(A)-0.1% formic acid solution(B) with the gradient elution. TOF and target MS/MS scanning mode was adopted. RESULTS The unknown sildenafil compound was found in samples. The fraction which analyzed by MSC and Chemispider was C₂₄H₃₄N₆O₄S₂. CONCLUSION This method can be used for rapid detection of unknown sildenafil substance which is illegally added in health care products.

Key words: UPLC-Q-TOF-MS health care products illegal added sildenafil substances