甘露聚糖肽联合他克莫司治疗白癜风的临床研究

Clinical Efficacy of Mannatide Combined with Tacrolimus Treatment on Vitiligo

关键词:  白癜风  甘露聚糖肽  他克莫司

Key words:  vitiligo  mannatide  tacrolimus

摘要:

目的 探讨甘露聚糖肽联合他克莫司治疗白癜风的临床疗效。方法 选取100例白癜风患者为研究对象，按随机数字表法分为观察组(n=50)和对照组(n=50)，对照组给予他克莫司，观察组给予甘露聚糖肽联合他克莫司。比较2组患者临床疗效、外周血T淋巴细胞亚群比例、血清白介素-6(interleukin-6，IL-6)和血清干扰素-γ(interferon-γ，IFN-γ)水平。结果 对照组和观察组治疗总有效率分别为62.0%和90.0%，组间比较差异具有统计学意义(P<0.05)。治疗后，观察组CD4+、CD8+、CD4+/CD8+分别为(44.9±3.6)%，(30.5±3.0)%，(1.9±0.2)；IFN-γ和IL-6分别为(38.5±4.7)，(109.9±6.2)ng·L^-1，对照组分别为(37.2±3.4)%，(35.7±2.7)%，(1.6±0.2)和(65.0±5.0)，(89.4±7.5)ng·L^-1，组间比较差异均具有统计学意义(P<0.05)。结论 甘露聚糖肽联合他克莫司治疗白癜风疗效确切，其可能作用机制为调节机体免疫平衡。

Abstract:

OBJECTIVE To evaluate the clinical efficacy of mannatide combined with tacrolimus treatment on vitiligo. METHODS All of 100 patients with vitiligo were randomly divided into observation group(n=50) and control group(n=50). The mannatide combined with tacrolimus was used in observation group and tacrolimus was used in control group. The clinical efficacy, peripheral blood T lymphocyte?subpopulation, serum interleukin-6 (IL-6) level and interferon-γ(IFN-γ) level were compared between the 2 groups. RESULTS The clinical efficacy of control group and observation group was 62.0% and 90.0%, respectively, the difference showed statistically significant (P<0.05). After treatment, the CD4+, CD8+, CD4+/CD8+ of observation group respectively was (44.9±3.6)%, (30.5±3.0)%, (1.9±0.2), IFN-γ and IL-6 was (38.5±4.7), and (109.9±6.2)ng·L^-1, those of control group was(37.2±3.4)%, (35.7±2.7)%, (1.6±0.2) and (65.0±5.0), and(89.4±7.5)ng·L^-1, the difference all showed statistically significant(P<0.05). CONCLUSION Using mannatide combined with tacrolimus treatment on vitiligo has definite effect, regulating the immune balance is its possible mechanism.