中草药与抗艾滋病病毒化学药物相互作用的研究进展

Research Progress on the Interaction Between Herb Medicine and Anti-HIV Chemical Drugs

关键词:  中草药  抗艾滋病病毒药物  药动学  CYP450代谢酶

Key words:  herb medicine  anti-HIV drugs  pharmacokinetics  CYP450 enzyme

摘要:

目的 HIV感染者由于免疫力低下导致各种机会性感染，中草药和化学药物联合用药的现象十分普遍。但是中草药成分复杂，可能影响抗病毒化学药物的有效性、安全性，引起HIV耐药等问题。本研究综述中草药与抗艾滋病病毒化学药物相互作用的研究进展。方法 从百度(www.baidu.com)和Pubmed (http://www.ncbi.nlm.nih.gov/pubmed/)中搜索有关“中草药(herb)、抗艾滋病病毒药物(anti-HIV drugs)、药物与药物相互作用(drug-drug interaction)”的文献，然后进行归纳整理。结果 综述了中草药与化学药物联合用药现状，中草药对抗病毒化学药物的药动学影响以及对CYP450代谢酶的作用。结论 系统地综述了中草药与抗艾滋病病毒化学药物的相互作用，为临床合理用药提供参考。

Abstract:

OBJECTIVE It is common for human immunodeficiency virus (HIV)-infected patients to use herb medicine due to all kinds of chance infections induced by low immunity. However, herb medicine is very complex, which may affect the clinical efficacy, safety of anti-HIV chemical drugs, even induce HIV resistance. In this work, we summarize the research progress of the interaction between herb and anti-HIV chemical drugs. METHODS Searched and summarized the papers with the key words of herb, anti-HIV drugs and drug-drug interaction from the internet of baidu (www.baidu.com) and pubmed (http://www.ncbi.nlm.nih.gov/pubmed/). RESULTS We summarized the co-administration status of herb medicine and anti-HIV drugs, the effect of pharmacokinetic and human cytochromo P450 (CYP450) enzymes of herb medicine on the anti-HIV chemical drugs. CONCLUSION In this manuscript, we systematically summarized the interaction between herb medicine and anti-HIV drugs, which might offer some clues for clinical therapy.