| 引用本文: | 李珊,陈文明,欧阳荣.乌药及其炮制品不同提取物镇痛作用的研究[J].中国现代应用药学,2015,32(11):1306-1308. |
| LI Shan,CHEN Wenming,OUYANG Rong.Studies on Analgesic Effects of Different Extract of Linderae Radix and It’s Processed Products[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(11):1306-1308. |
|
| 摘要: |
| 目的 研究乌药及其炮制品不同提取物的镇痛作用。方法 采用醋酸致痛模型和痛经模型，观察不同剂量乌药水提物、醇提物、醚提物和不同剂量醋制乌药水提物、醇提物、醚提物对小鼠的镇痛作用。结果 醋酸致痛模型实验中，与正常对照组相比，乌药和醋制乌药水提、醇提高剂量组能明显减少小鼠扭体次数(P<0.05)；痛经模型实验中，与模型组比较，醋制乌药水提和醇提高剂量组能明显减少小鼠扭体次数(P<0.05)。结论 乌药、醋制乌药的水提液和醇提液具有镇痛作用，醋制乌药的镇痛作用优于乌药。 |
| 关键词: 乌药 醋制乌药 提取物 镇痛 痛经模型 醋酸致痛模型 |
| DOI： |
| 分类号: |
| 基金项目:湖南省长沙市科技计划项目(K1307035-31) |
|
| Studies on Analgesic Effects of Different Extract of Linderae Radix and It’s Processed Products |
|
LI Shan, CHEN Wenming, OUYANG Rong
|
|
Pharmacy Department of The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China
|
| Abstract: |
| OBJECTIVE To study the analgesic effects of different extract of Linderae Radix and Vinegar Lindera. METHODS Used pain model induced by acetic acid and dysmenorrheal model, observed the analgesic effects of different doses of Linderae Radix and Vinegar Lindera aqueous extract, alcohol extract, ether extract effect on mice. RESULTS In the experimental of pain model induced by acetic acid, compared with normal control group, high dose aqueous extract, alcohol extract of Linderae Radix and high dose aqueous extract, alcohol extract of Vinegar Lindera could significantly reduce the writhing times of mice. In the experimental of dysmenorrheal model, compared with model group, high dose aqueous extract, alcohol extract of Vinegar Lindera could significantly reduce the writhing times of mice. CONCLUSION The aqueous extract, alcohol extract of Linderae Radix and Vinegar Lindera have analgesic effect, Vinegar Lindera have superior analgesic effect than Lindera. |
| Key words: Linderae Radix Vinegar Lindera extract analgesia dysmenorrheal model pain model induced by acetic acid |
