伏立康唑对格列奈类药物降低糖尿病大鼠血糖作用的影响

Effect of Voriconazole on the Hypoglycemic Effect of Non-sulfonylureas in Diabetic Rats

关键词:  伏立康唑  瑞格列奈  那格列奈  降糖作用

Key words:  voriconazole  repaglinide  nateglinide  hypoglycemic effect

摘要:

目的 研究伏立康唑对格列奈药物降低正常和糖尿病大鼠的血糖效应的影响。方法 ①正常大鼠随机分为2组，正常组和伏立康唑组，伏立康唑组大鼠连续灌胃7 d，第8天禁食8 h后于0，1，3，6，9，12，18，24 h眼眶取血，测定血糖。②正常大鼠随机分为4组，瑞格列奈组、瑞格列奈+伏立康唑组、那格列奈组和那格列奈+伏立康唑组。合并用药组伏立康唑连续灌胃7 d，第8天禁食8 h，4组大鼠用对应的格列奈药物灌胃，给药后于0，1，3，6，9，12，18，24?h眼眶取血，测定血糖。③STZ诱导糖尿病大鼠，分组及给药方式同第2部分实验。结果 治疗剂量的伏立康唑增强瑞格列奈和那格列奈在正常和糖尿病大鼠的降糖效应。结论 格列奈降糖药物与伏立康唑合并使用时可能需要调整剂量。

Abstract:

OBJECTIVE To investigate the effect of voriconazole on the hypoglycemic effect of non-sulfonylureas in nomal and streptozotocin(STZ)-induced diabetic rats. METHODS ①nomal rats were randomly divided into 2 groups: control group and voriconazole group. The later group animals received voriconazole intragastricly for 7 consecutive days. On 8th day, all the animals were fasted for 8 h, and blood samples were drawn from orbit at regular interval of 0, 1, 3, 6, 9, 12, 18, 24 h. Then fasting blood glucose was measured. ②Nomal rats were randomly divided into 4 groups: group Ⅰ rats just received repaglinide, and group Ⅱ rats received repaglinide and voriconazole. Group Ⅲ rats received nateglinide, and group Ⅳ rats received nateglinide and voriconazole. Group Ⅱ and Ⅳ rats received voriconazole intragastricly for seven consecutive days. On 8th day, all the animals were fasted for 8 h, and blood samples were drawn from orbit at regular interval of 0, 1, 3, 6, 9, 12, 18, 24 h. Then fasting blood glucose was measured. ③Wistar rats received STZ to induce diabetes mellitus. The methods of grouping and giving drug were the same as the second part of experiments. RESULTS Therapeutic dose of voriconazole enhanced the hypoglycemic effect of repaglinide and nateglinide in nomal and diabetic rats. CONCLUSION The results indicate that the dose of non-sulfonylureas needs to be adjusted if co-administered with voriconazole.