| 引用本文: | 熊晴,王小平,鲁梦霞,黄娟,童胜强.液液平衡手性萃取拆分的研究进展[J].中国现代应用药学,2015,32(11):1408-1413. |
| XIONG Qing,WANG Xiaoping,LU Mengxia,HUANG Juan,TONG Shengqiang.Progress on Enantioselective Liquid-Liquid Extraction[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(11):1408-1413. |
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| 摘要: |
| 目的 介绍液液平衡手性萃取拆分技术的基本原理，总结近年来液液平衡手性萃取拆分的研究进展。方法 根据手性选择剂的分类，对近年来液液平衡手性萃取拆分的最新应用研究情况做了介绍。结果 总结归纳了5大类手性选择剂的应用，包括过渡金属络合物、酒石酸衍生物、冠醚类、β-环糊精衍生物及金鸡纳碱类，并简要介绍了液液萃取拆分相关模型研究。结论 液液平衡手性萃取拆分技术分离效果良好，适用性强，易于实现工业规模，有望成为制备型分离外消旋体化合物的先进技术。 |
| 关键词: 液液平衡手性萃取拆分 手性分离 手性试剂 研究进展 |
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| 基金项目:国家自然科学基金(21105090)；浙江省高等学校中青年学科带头人攀登项目(pd2013031) |
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| Progress on Enantioselective Liquid-Liquid Extraction |
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XIONG Qing1, WANG Xiaoping1, LU Mengxia1, HUANG Juan2, TONG Shengqiang1
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1.Zhejiang University of Technology, Hangzhou 310032, China;2.Zhejiang Province Institute of Veterinary Drug and Feed Control, Hangzhou 310020, China
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| Abstract: |
| OBJECTIVE To introduce the principle of enantioselective liquid-liquid extraction, and to review the progress on enantioselective liquid-liquid extraction in recent years. METHODS The recent progress on enantioselective liquid-liquid extraction was systematically reviewed according to the classification of chiral selectors. RESULTS Five typical types of chiral selector were summarized, including transitional metal complexes, tartaric acid derivatives, crown ethers, β-cyclodextrin derivatives and cinchona alkaloids. Meanwhile, studies on modeling and reaction kinetics of this technique were mentioned. CONCLUSION Enantioselective liquid-liquid extraction is an ideal resolution technology for preparative enantioseparation of racemates due to its high separation efficiency and ease-to-be scaled up characteristics. |
| Key words: enantioselective liquid-liquid extraction chiral separation chiral selector progress |
