Dvl交叉调控Wnt及NF-κB信号通路在类风湿性关节炎骨侵蚀中的作用研究进展

Research Progress of Regulating Effects of Dvl on Bone Erosion in Rheumatoid Arthritis by Crosstalk Between Wnt and NF-κB Signalling Pathway

关键词:  类风湿性关节炎  Wnt 通路  NF-κB通路  Dvl  破骨细胞  成骨细胞

Key words:  rheumatoid arthritis  Wnt  NF-κB  dishevelled  osteoclast  osteoblast

摘要:

Wnt信号通路在骨细胞的成熟、分化和凋亡过程中具有重要的调控作用，通过调控成骨细胞和破骨细胞从而达到骨代谢的动态平衡。Wnt通路激活不足或过度激活均参与了类风湿性关节炎的发生和发展。核因子κB(NF-κB)是一种具有多向性调节作用的转录因子，参与细胞的生长、发育、凋亡等多种生理功能。如果NF-κB通路被不适当的活化，则可导致多种自身免疫和炎症性疾病，这其中就包括类风湿性关节炎。Dvl蛋白是Wnt信号通路中关键蛋白，有研究发现其也参与NF-κB通路的调控。因此，通过对Dvl蛋白交叉调控Wnt和NF-κB通路的研究，有可能为我们提供治疗类风湿关节炎新的药物靶点。

Abstract:

The Wnt signalling cascades have essential roles in development, growth and homeostasis of skeleton through regulating osteoblasts and osteoclasts. Lack or excessive of Wnt signalling pathway activation could impair repair of erosion of rheumatoid arthritis. NF-κB is a kind of multi-directional regulation of transcription factors, involved in a variety of physiological functions like cell growth, development and apoptosis. Inappropriate NF-κB activity has been linked with many autoimmune and inflammatory diseases, including rheumatoid arthritis. Dvl is a key protein in the Wnt signaling pathway, and studies have found that it is also involved in the regulation of NF-κB pathway. Therefore, research on crosstalk between Wnt and NF-κB signalling pathway and its associates may facilitate development of specific therapeutic interventions for rheumatoid arthritis targeting the two pathway.