| 引用本文: | 陈瑛,王丹丹,朱虹,何俏军,杨波.抗肿瘤新靶点黏着斑激酶FAK及其抑制剂研究进展[J].中国现代应用药学,2016,33(2):255-260. |
| CHEN Ying,WANG Dandan,ZHU Hong,HE Qiaojun,YANG Bo.Research and Development of Focal-Adhesion Kinase(FAK) and the Inhibitors[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(2):255-260. |
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| 摘要: |
| FAK是细胞内一种非受体酪氨酸激酶，参与胞内多条信号通路的传导。FAK在多种类型的肿瘤细胞中都出现表达量和活性上调现象，通过激酶依赖和非激酶依赖机制参与肿瘤细胞侵袭、转移、增殖、生长和抗凋亡等多个过程，是目前研究较多的抗肿瘤靶点之一。多个不同机制的FAK抑制剂正处于临床前研究和临床试验阶段，能够抑制特定类型肿瘤的生长、转移等。本文对近年来FAK与肿瘤的关系以及FAK抑制剂抗肿瘤作用的研究进展进行综述。 |
| 关键词: 黏着斑激酶(FAK) 肿瘤 FAK抑制剂 |
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| Research and Development of Focal-Adhesion Kinase(FAK) and the Inhibitors |
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CHEN Ying, WANG Dandan, ZHU Hong, HE Qiaojun, YANG Bo
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Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
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| Abstract: |
| Focal adhesion kinase(FAK) is a non-receptor tyrosine kinase in cell, involved in several cellular signaling pathways. FAK is overexpressed and activated in several tumors, and controls the processes of invasion, metastasis, proliferation, growth and survival in tumor cells through both kinase-dependent and kinase-independent pathways. Therefore, FAK becomes an anti-tumor target and has been investigated widely in the past few years. Several FAK inhibitors are under preclinical research or in the clinical trial, which can suppress the growth and metastasis of certain tumor cells. In this paper, the relationship between FAK and tumor and the research of FAK inhibitors is reviewed. |
| Key words: focal adhesion kinase(FAK) tumor FAK inhibitors |
