| 引用本文: | 金婧,刘雪松.沉降篮对盐酸罗匹尼罗缓释片释放度的影响[J].中国现代应用药学,2016,33(2):190-193. |
| JIN Jing,LIU Xuesong.Effect of Sinker on Dissolution Release of Ropinirole Hydrochloride Extended-release Tablet[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(2):190-193. |
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| 摘要: |
| 目的 研究沉降篮对盐酸罗匹尼罗缓释片释放度的影响。方法 在FDA推荐的释放度检测方法基础上，比较增加沉降篮前后，盐酸罗匹尼罗缓释片在各取样时间点释放度的变化情况。结果 增加沉降篮后，盐酸罗匹尼罗缓释片释放度结果没有明显变化，但相同时间点不同片之间RSD明显变小。结论 沉降篮可以有效控制盐酸罗匹尼罗缓释片位置，得到稳定的结果，更有利于产品质量控制。 |
| 关键词: 盐酸罗匹尼罗缓释片 释放度 沉降篮 |
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| Effect of Sinker on Dissolution Release of Ropinirole Hydrochloride Extended-release Tablet |
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JIN Jing1, LIU Xuesong2
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1.Zhejiang Huahai Pharmaceuticals Co., Ltd., Linhai 317024, China;2.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
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| Abstract: |
| OBJECTIVE To research the effect of sinker on dissolution of Ropinirole Hydrochloride Extended-release tablet. METHODS according to the dissolution method from FDA, the release of Ropinirole Hydrochloride Extended-release tablet at each time point was compared between without and with sinker. RESULTS adding sinkers could efficiently improve the RSD, but less affect the product whole dissolution rate. CONCLUSION sinkers can control the position of tablet sinking in the vessel. Data are more stable. It is suitable for the product. |
| Key words: Ropinirole Hydrochloride Extended-release tablet dissolution sinker |
