| 引用本文: | 王薇,康斯丹,王跃鑫,黄巧玲,胡毅翔,余陈欢.克白颗粒镇静抗疲劳作用研究[J].中国现代应用药学,2016,33(3):297-300. |
| WANG Wei,KANG Sidan,WANG Yuexin,HUANG Qiaoling,HU Yixiang,YU Chenhuan.Sedative and Anti-fatigue Effects of Kebai Particles[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(3):297-300. |
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| 摘要: |
| 目的 观察克白颗粒的镇静抗疲劳作用。方法 小鼠灌胃给予克白颗粒2.26，4.52，9.04 g·kg-1，观察克白颗粒对小鼠神经系统、游泳时间以及缺氧耐受能力的影响。结果 不同剂量的克白颗粒对小鼠一般行为学及自主活动没有显著影响，9.04 g·kg-1克白颗粒能显著延长小鼠睡眠潜伏期时间和睡眠时间，并且能延长小鼠的耐缺氧时间(P<0.05)，4.52，9.04 g·kg-1的克白颗粒能显著延长小鼠的游泳时间(P<0.01)。结论 克白颗粒具有一定的镇静和抗疲劳作用。 |
| 关键词: 克白颗粒 抗疲劳 安全性评价 |
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| 基金项目:浙江省药学会医院药学专项科研资助项目(2013ZYY24) |
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| Sedative and Anti-fatigue Effects of Kebai Particles |
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WANG Wei1, KANG Sidan1, WANG Yuexin1, HUANG Qiaoling1, HU Yixiang2, YU Chenhuan2
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1.The Third People’s Hospital of Hangzhou City, Hangzhou 310003, China;2.Zhejiang Key Laboratory of Experimental Animal and Safety Evaluation, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China
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| Abstract: |
| OBJECTIVE To determine the sedative and anti-fatigue effects of Kebai particles. METHODS Mice were treated with 2.26, 4.52, 9.04 g·kg-1 Kebai particles orally to determine the influence on nervous system, swimming time and hypoxia tolerance ability of animals. RESULTS Three dosages of Kebai particles had no obvious influence on spontaneous activity and coordinated movement in mice, while high dosage of Kebai particles (9.04 g·kg-1) had influence on sleep latency period and sleep duration, and could prolong the hypoxia tolerance time (P<0.05). Kebai particles could significantly prolong the swimming time of mice at the doses of 9.04, 4.52 g·kg-1. CONCLUSION Kebai particles has sedative and anti-fatigue effect. |
| Key words: Kebai particles anti-fatigue safety evaluation |
