| 引用本文: | 王瑛,金捷,金祖汉,李建淼,毛培江,杨毅,黄晶晶,李明焱.灵芝孢子粉增强免疫功能的研究[J].中国现代应用药学,2016,33(5):544-546. |
| WANG Ying,JIN Jie,JIN Zuhan,LI Jianmiao,MAO Peijiang,YANG Yi,HUANG Jingjing,LI Mingyan.Study on Immune-enhancing Effects of Ganoderma Lucidum Spore Powder[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(5):544-546. |
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| 灵芝孢子粉增强免疫功能的研究 |
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王瑛1,2, 金捷3, 金祖汉3, 李建淼1,2, 毛培江3, 杨毅3, 黄晶晶3, 李明焱1,2
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1.金华寿仙谷药业有限公司，浙江 武义 321200;2.浙江省珍稀植物药工程技术研究中心，浙江 武义 321200;3.浙江省中药研究所有限公司，杭州 310023
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| 摘要: |
| 目的 研究灵芝孢子粉(破壁)的增强免疫作用。方法 通过ConA诱导的小鼠脾淋巴细胞转化实验、绵羊红细胞诱导的小鼠迟发型变态反应实验(足跖容积法)、抗体生成细胞检测实验(Jerne改良玻片法)、血清溶血素测定(血凝法)、小鼠碳廓清实验、小鼠腹腔巨噬细胞吞噬鸡红细胞实验(半体内法)、NK细胞活性实验(乳酸脱氢酶测定法)评价灵芝孢子粉增强免疫功效。结果 ConA诱导的小鼠脾淋巴细胞转化实验、迟发型变态反应实验、抗体生成细胞检测实验、腹腔巨噬细胞吞噬鸡红细胞实验4项实验结果均为阳性。结论 灵芝孢子粉(破壁)样品具有增强免疫作用。 |
| 关键词: 灵芝孢子粉 增强免疫功能 |
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| 基金项目:浙江省珍稀植物药工程技术研究中心(2012E10029) |
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| Study on Immune-enhancing Effects of Ganoderma Lucidum Spore Powder |
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WANG Ying1,2, JIN Jie3, JIN Zuhan3, LI Jianmiao1,2, MAO Peijiang3, YANG Yi3, HUANG Jingjing3, LI Mingyan1,2
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1.Jinhua Shouxiangu Pharmaceutical Co., Ltd., Wuyi 321200, China;2.Zhejiang Engineering Research Center of Rare Plant Medicine, Wuyi 321200, China;3.Zhengjiang Rearch Institute of Traditional Chinese Medicine, Hangzhou 310023, China
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| Abstract: |
| OBJECTIVE To investigate the immune-enhancing effects of shell-broken ganoderma lucidum spore powder. METHODS The immune-enhancing effects were evaluated by ConA-induced mice lymphocyte transformation test, sheep red blood cell-induced delayed-type hypersensitivity (DTH) test (foot volume method), antibodies formation in spleens (modified Jerne’s method), serum hemolysin (blood agglutination method), carbon clearance test, phagocytic function of mice macrophages against cock erythrocytes (in-half body method), NK cell activity test (lactate dehydrogenase method). RESULTS The ConA-induced mice lymphocyte transformation test, DTH test, antibodies formation in spleens test and phagocytic function of mice macrophages against cock erythrocytes test showed positive results. CONCLUSION The ganoderma lucidum spore powder showes good immune-enhancing effects. |
| Key words: ganoderma spore powder immune-enhancing effects |
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