异丙酚在容量控制性失血性休克猪体内的药动学研究

张浩; 夏艳萍; 陈克研; 刁玉刚<sup>*</sup>; 张铁铮

引用本文:	张浩,夏艳萍,陈克研,刁玉刚,张铁铮.异丙酚在容量控制性失血性休克猪体内的药动学研究[J].中国现代应用药学,2016,33(6):771-774.
	ZHANG Hao,XIA Yanping,CHEN Keyan,DIAO Yugang,ZHANG Tiezheng.Pharmacokinetics of Propofol in Pigs with Hemorrhagic Shock Under Volume Controlled[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(6):771-774.

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异丙酚在容量控制性失血性休克猪体内的药动学研究
张浩^1,2, 夏艳萍^1,3, 陈克研¹, 刁玉刚¹, 张铁铮¹
1.锦州医科大学沈阳军区总医院研究生培养基地，沈阳 110016;2.淮安市妇幼保健院，江苏淮安 223002;3.滨州医学院附属医院，山东滨州 256603

摘要:

目的探讨异丙酚在容量控制性失血性休克猪体内药动学的特点。方法健康巴马小型猪12头，应用随机数字表法将其随机分为对照组和休克组。采用HPLC-荧光法测定猪静脉泵入异丙酚后不同时间点的血药浓度。根据测定的血药浓度计算异丙酚的消除半衰期(t_1/2)，血浆-效应室平衡速率常数(K_e0)，药时曲线面积(AUC)以及平均驻留时间(MRT)等药动学参数。结果休克组异丙酚的血药浓度高于对照组，差异有显著性(P<0.05)。休克组最大药物浓度(C_max)高于对照组，差异有显著性(P<0.05)。休克组t_1/2较对照组延长，差异有显著性(P<0.05)。休克组MRT较对照组延长，差异有显著性(P<0.05)。休克组的K_e0、AUC较对照组增大，差异无统计学意义。结论容量控制性失血性休克猪异丙酚的药动学特点是代谢减慢：药物的消除半衰期延长，血浆-效应室平衡速率常数增大，体内的平均驻留时间延长。

关键词: 失血性休克异丙酚药动学

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基金项目:军队后勤科研重点项目(BWS12J008)

Pharmacokinetics of Propofol in Pigs with Hemorrhagic Shock Under Volume Controlled

ZHANG Hao^1,2, XIA Yanping^1,3, CHEN Keyan¹, DIAO Yugang¹, ZHANG Tiezheng¹

1.Jinzhou Medical University Postgraduate Training in General Hospital of Shenyang Military Region Base, Shenyang 110016, China;2.Huaian Maternity and Child Health Hospital, Huaian 223002, China;3.Affiliated Hospital of Binzhou Medical University, Binzhou 256603, China

Abstract:

OBJECTIVE to investigate the characteristics of pharmacokinetics of propofol in pigs with hemorrhagic shock under volume controlled. METHODS twelve bama mini pigs were randomly divided into control group, hemorrhagic shock group. The plasma concentration of propofol in pigs was analyzed by HPLC-fluorescence at different time points after the start of the infusion propofol. According to the plasma concentration of propofol to calculate the elimination half-life (t_1/2) of propofol, the plasma-effect site equilibration rate content (K_e0), the drug’s area under the curve (AUC), the mean residence time (MRT) and the other pharmacokinetic parameters. RESULTS Plasma concentration of propofol in hemorrhagic shock group was higher than control group significantly(P<0.05). Maximum drug concentration(C_max) in hemorrhagic shock group was higher than control group significantly(P<0.05). The t_1/2 in hemorrhagic shock group was longer than control group significantly(P<0.05). The MRT in hemorrhagic shock group was longer than control group significantly(P<0.05). The K_e0 and AUC of hemorrhagic shock group was higher than that of control group, there was not significant difference between groups. CONCLUSION The characteristic of pharmacokinetics of propofol in pigs with hemorrhagic shock under volume controlled was that metabolism delayed, elimination half-life was longer, so dose the mean residence time, the plasma-effect site equilibration rate content was diminished.

Key words: hemorrhagic shock propofol pharmacokinetics