温肾调经汤对多囊卵巢综合征内分泌及脂代谢的影响

Influence of Wenshen Tiaojing Decoction on Endocrine and Lipid Metabolism of Polycystic Ovary Syndrome Patients

关键词:  肾调经汤  二甲双胍  多囊卵巢综合征  脂代谢  性激素  胰岛素抵抗

Key words:  Wenshen tiaojing Decoction  metformin  Polycystic Ovary Syndrome(PCOS)  lipid metabolism  sex hormone  insulin resistance

摘要:

目的 探讨温肾调经汤对多囊卵巢综合征(PCOS)患者内分泌及脂代谢的影响。方法 将符合纳入标准的90例患者采用随机数字表法分为2组，每组各45例，观察组选用温肾调经汤治疗，对照组选用二甲双胍治疗，2组用药时间均为2个月，比较2组治疗前后体质量指数(BMI)、空腹血糖、餐后2 h血糖、空腹胰岛素、餐后2 h胰岛素、瘦素、脂联素、稳态胰岛素评价指数(HOMA-IR)、血脂及性激素的变化，并进行中医证候评分。结果 通过2个月的治疗，温肾调经汤比二甲双胍能更好地降低肥胖型PCOS患者的平均BMI，调节性激素和大部分脂代谢(除高密度脂蛋白胆固醇、载脂蛋白A外)，降低中医症候评分，差异有统计学意义(P<0.05)。2组患者降低血糖、胰岛素抵抗疗效相仿。结论 温肾调经汤可降低肥胖患者BMI，改善胰岛素抵抗，调整PCOS患者性激素水平，改善脂代谢异常，降低中医证候评分。

Abstract:

OBJECTIVE To observe the effect of Wenshen tiaojing Decoction on the endocrine and lipid metabolism of Polycystic Ovary Syndrome (PCOS) patients. METHODS Ninety PCOS patients were randomly divided into the treatment group and the control group(n=45). The treatment group was given Wenshen tiaojing decoction. The control group was treated with metformin. Both groups were treated for 2 months. The changes before and after the treatment in average body mass index (BMI), fasting blood-glucose, 2 hour postprandial blood glucose, fasting insulin, postprandial 2 h insulin, leptin, adiponectin, HOMA-IR, blood lipid, sex hormone and TCM syndrome grade were compared. RESULTS Through the 2 months treatment, The effect of Wenshen tiaojing Decoction on the decrease of the BMI, adjustion sex hormone and most of the lipid metabolism index (except for HDL-C and Apo A), and the reduction of the TCM symptom score were better than that of metformin, significantly(P<0.05). The reduction of blood glucose and insulin resistance in both groups were similar. CONSLUSION Wenshen tiaojing Decoction could lower BMI of the obese patients, improve abnormal lipid metabolism, adjust sex hormone and lower the TCM syndrome scores of PCOS patients.