| 引用本文: | 赵艳雪,冯彩霞,刘勋涛,田伟,曹金娜.水飞蓟宾自乳化制剂对CCl4所致肝损伤的保护作用[J].中国现代应用药学,2016,33(8):1006-1009. |
| ZHAO Yanxue,FENG Caixia,LIU Xuntao,TIAN Wei,CAO Jinna.Protective Effects of Silybin Self-emulsifying Drug Delivery Systems on Acute Liver Injury Induced by CCl4[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(8):1006-1009. |
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| 摘要: |
| 目的 探讨水飞蓟宾自乳化制剂对CCl4所致急性肝损伤的保护作用。方法 以CCl4所致小鼠急性肝损伤为模型，以生理盐水为阴性对照，以联苯双酯为阳性对照，以水飞蓟宾混悬剂为参比，以血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)和肝脏中谷胱甘肽过氧化物酶(GSH-PX)活性及肝脏病理组织切片检查为指标，对比研究水飞蓟宾自乳化制剂对CCl4所致急性肝损伤的保护作用。结果 水飞蓟宾自乳化制剂能显著的抑制CCl4所致的血清ALT和AST活性升高，使肝脏中的GSH-PX维持在正常水平，保护肝脏并避免其发生严重病变。结论 水飞蓟宾自乳化制剂对CCl4所致急性肝损伤有保护作用。 |
| 关键词: 水飞蓟宾 自乳化 四氯化碳 急性肝损伤 |
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| Protective Effects of Silybin Self-emulsifying Drug Delivery Systems on Acute Liver Injury Induced by CCl4 |
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ZHAO Yanxue1, FENG Caixia1, LIU Xuntao2, TIAN Wei2, CAO Jinna3
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1.The Fifth Hospital of Shijiazhuang, Shijiazhuang 050021, China;2.CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd, Shijiazhuang 050035, China;3.Northeast Pharmaceutical Group Co., Ltd., Shenyang 110014, China
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| Abstract: |
| OBJECTIVE To explore the protective effects of silybin self-emulsifying drug delivery systems on acute liver injury induced by CCl4. METHODS Saline and bifendate were selected as negative and positive control, respectively. The protective effects of silybin self-emulsifying drug delivery systems on acute liver injury induced by CCl4 was evaluated by the levels of ALT and AST in plasma, glutathione peroxidase in liver and liver histopathology, and compared with silybin suspension. RESULTS Silybin self-emulsifying drug delivery systems inhibited the increase of the ALT and AST in serum markedly, maintained the normal level of GSH-PX in liver and protect liver from lesion. Conclusion Silybin self-emulsifying drug delivery system has protectived effect on acute liver injury induced by CCl4. |
| Key words: silybin self-emulsifying drug delivery systems CCl4 acute liver injury |
