白芍总苷联合抗组胺药治疗慢性荨麻疹疗效和安全性的Meta分析

Meta Analysis of Efficacy and Safety of the Traditional Chinese Medicine Total Glucosides of Peony Combined with Antihistamines in Treatment of Chronic Urticaria

关键词:  慢性荨麻疹  meta分析  白芍总苷  疗效  安全性

Key words:  chronic urticaria  meta analysis  total glucosides of peony  efficiency  safety

摘要:

目的 评价中药白芍总苷（total glucosides of peony，TGP）联合抗组胺药治疗慢性荨麻疹的疗效和安全性。方法 计算机检索中国知网（CNKI）、维普数据库（VIP）、万方数据、PubMed、EMbase、Cochrane图书馆（各数据库检索时间均从创建至2015年9月），收集相关文献。根据纳入和排除标准筛选并提取资料，采用RevMan 5.2软件进行Meta分析。结果 共纳入19项研究，1 606例患者。Meta分析结果显示，白芍总苷辅助试验组的疗效优于对照组，2组相比总有效率（P<0.000 01）、咪唑斯汀（P<0.000 01）、西替利嗪（P=0.000 4）、地氯雷他定（P<0.000 01）、非索非那定（P<0.000 1）、依巴斯汀（P<0.002）；不良反应分析提示，试验组的不良反应发生率高于对照组，差异有统计学意义（P=0.009）。结论 基于现有临床证据，白芍总苷联合抗组胺药治疗慢性荨麻疹的疗效确切，但腹泻发生率明显增加。

Abstract:

OBJECTIVE To evaluate the efficacy and safety of total glucosides of peony(TGP) combined with antihistamines in the treatment of chronic urticaria. METHODS CNKI, VIP, Wanfang, PubMed, EMbase and Cochrane library database were researched, and the randomized controlled trials of TGP combined antihistamines for treatment of chronic urticarial were collected. Data were extracted and evaluated by two reviewers independently with a designed extraction form. The RevMan 5.2 software was used to carry out meta analysis. RESULTS The 19 studies invoving 1 606 patients were included. The results of meta-analysis indicated that the treatment success rate of TGP combined with antihistamines was significantly higher than that of antihistamines(P<0.000 01). Subgroup-analysis showed that the TGP significantly increased the efficacy of mizolastine(P<0.000 01), cetirizine(P=0.000 4), and desloratadine(P<0.000 01), fexofenadine(P<0.000 1) and ebastine(P<0.002). The incidence of diarrhea in the treated group were also higher than that of the control group(P=0.009). CONCLUSION TGP combined antihistamines in the treatment of chronic urticaria is effective, but had more adverse events of diarrhea.