| 引用本文: | 毛孝钢,周华,张媛媛,应晶晶,龚继勇.β-内酰胺类抗菌药物致药物热的研究[J].中国现代应用药学,2016,33(6):822-824. |
| MAO Xiaogang,ZHOU Hua,ZHANG Yuanyuan,YING Jingjing,GONG Jiyong.Study on the Drug Fever Caused by β-amide Antibiotics[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(6):822-824. |
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| 摘要: |
| 目的 分析β-内酰胺类抗菌药物致药物热的临床表现及诊治方法，为临床抗感染治疗中及时准确判断药物热提供参考。方法 对2014年1月—2015年12月宁波地区4家三甲医院发生的β-内酰胺类抗菌药物致药物热的用药情况、临床表现、辅助检查等进行统计分析。结果 β-内酰胺类抗菌药物致药物热的病例共41例，其中哌拉西林他唑巴坦钠居第1位18例(43.9%)，其次为头孢曲松6例(14.6%)，头孢地嗪5例(12.1%)。11例仅有发热表现(26.8%)，其余30例伴有不同的临床表现。所有患者停药后体温恢复正常。结论 临床药师应利用自己的专业优势，协助临床医师尽早诊治药物热。 |
| 关键词: 药物热 β-内酰胺类 抗菌药物 |
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| Study on the Drug Fever Caused by β-amide Antibiotics |
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MAO Xiaogang1, ZHOU Hua1, ZHANG Yuanyuan2, YING Jingjing3, GONG Jiyong4
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1.Pharmacy of Ningbo Lihuili Hospital, Ningbo 315040, China;2.The Affiliated Hospital of School of Medicine of Ningbo University, Ningbo 315040, China City;3.The Second Hospital of Ningbo, Ningbo 315000, China;4.The First Hospital of Ningbo City, Ningbo 315010, China
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| Abstract: |
| OBJECTIVE To analyze the clinical manifestations and the diagnosis treatments of drug fever caused by β-amide antibiotics, and to provide reference for the timely and accurate judgment and anti infective therapy of drug fever. METHODS Collected the case of drug fever caused by β-amide antibiotics in four third-grade class-A hospitas from January 2014 to December 2015, analyzed the drug situation, clinical manifestation, auxiliary examination and so on. RESULTS forty-one cases of drug fever caused by beta lactam antibacterial, the most of drug fever caused by piperacillin hetazobactam sodium, 18 cases (43.9%), followed by ceftriaxone in 6 cases (14.6%), 5 cases of cefodizime (12.1%). Eleven cases with only fever performance (26.8%), the remaining 30 cases accompanied by a variety of clinical manifestations. forty cases recovered to normal after stopping the drug. CONCLUSION Clinical pharmacists should make use of their professional advantages to assist clinicians in the early diagnosis and treatment of drug fever. |
| Key words: drug fever beta-amide antibiotics |
