节拍式化疗用于晚期卵巢癌的临床研究进展

Clinical Research Progress of Metronomic Chemotherapy in Advanced Ovarian Cancer

关键词:  节拍式化疗  卵巢癌

Key words:  metronomic chemotherapy  ovarian cancer

摘要:

节拍式化疗是近年来兴起的一种低剂量、高频率、持续性的给药模式，通过抑制肿瘤血管内皮细胞增殖，影响肿瘤干细胞，调节机体免疫系统，从而控制肿瘤生长。节拍式化疗可使晚期卵巢癌患者疾病得到控制，改善患者的生活质量，较传统的最大耐受剂量化疗不良反应发生率较低，不易耐药，有望成为后期癌症患者治疗的新策略。

Abstract:

Metronomic chemotherapy is a new dosing form of chemotherapy which is in low-dosages with high frequency and continuous administration that has been rising in recent years. It can sustainably inhibit the proliferation of tumor endothelial cell, affect tumor stem cells and regulate the body's immune system. Metronomic chemotherapy may lead to disease under control in patients with advanced ovarian cancer, compared with the traditional maximum tolerated dose chemotherapy, metronomic chemotherapy is in low incidence of adverse reactions, without resistant and in good response rate, this scheme is effective for advanced ovarian cancer patients. At present, in the clinical studying with the role of metronomic chemotherapy in patients with advanced ovarian cancer, it has a positive treatment responses, which will become the new strategy for the advanced cancer patients, and improves the patient's quality of life.