注射用质子泵抑制剂超说明书用药调查分析

Survey on Off-Label Drug Use of Proton Pump Inhibitors for Injection

关键词:  注射用质子泵抑制剂  超说明书用药  住院患者

Key words:  proton pump inhibitors for injection  off-label drug use  hospitalized patients

摘要:

目的 回顾性调查某综合性三甲医院住院患者注射用质子泵抑制剂超说明书用药情况。方法 统计2014年住院患者使用注射用质子泵抑制剂的用药医嘱，按照药品说明书规定的内容，分析是否存在超说明书用药，统计超说明书用药的类型。结果 共抽样分析用药医嘱3 271条，30个科室(共34个)存在超说明书用药情况，总发生率为90.74%，类型以超适应症为主。其中注射用兰索拉唑、注射用埃索美拉唑、注射用奥美拉唑、注射用泮托拉唑、注射用奥美拉唑超说明书用药发生率分别为98.72%，99.30%，10.67%，94.91%，100%。结论 注射用质子泵抑制剂在该院被普遍使用，超说明书用药情况较为突出，应通过管控措施规范超说明书用药行为，促进临床合理用药。

Abstract:

OBJECTIVE To determine the extent of off-label drug use of proton pump inhibitors for injection in a 3A grade general hospital’s hospitalized patients in 2014. METHODS Prescriptions contains proton pump inhibitors for injection were collected from 2014 for a statistical analysis regarding the general information of hospitalized patients, the status of drug use and the off-label use status. RESULTS A total of 3 271 medical advices were extracted and analyzed, with incidence rates of off-label drug use accounting for 90.74%, covering all 30 departments. The main categories of off-label drug use was indication. The rates of off-label drug use about lansoprazole, esomeprazole, omeprazole, pantoprazole, omeprazole account for 98.72%, 99.30%, 10.67%, 94.91%, 100%. CONCLUSION Proton pump inhibitors is widely used in the hospital, and off-label drug use of proton pump inhibitors is commonly-seen. Control measures should be adopted to regulate the specification of drug use behavior to pronote clinical rational drug use.