| 引用本文: | 蒋正立,张慧敏,胡小铭,杨建苗,许东航.1例临床药师参与美罗培南联用丙戊酸钠的临床实践[J].中国现代应用药学,2016,33(12):1580-1583. |
| JIANG Zhengli,ZHANG Huimin,HU Xiaoming,YANG Jianmiao,XU Donghang.One Case of Clinical Pharmacists Participating in the Clinical Practice of Meropenem Combined with Valproic Acid[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(12):1580-1583. |
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| 1例临床药师参与美罗培南联用丙戊酸钠的临床实践 |
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蒋正立1,2, 张慧敏2, 胡小铭2, 杨建苗2, 许东航1,3
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1.浙江大学, 杭州 310058;2.浙江省台州医院, 浙江 临海 317000;3.浙江大学医学院附属第二医院, 杭州 310009
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| 摘要: |
| 目的 总结临床药师参与1例颅脑术后患者美罗培南联用丙戊酸钠的临床实践，为患者合理用药提供参考建议。方法 临床药师通过分析1例颅脑术后美罗培南联用丙戊酸钠引起丙戊酸钠血药浓度明显下降的案例，提出血药浓度监测和给药方案建议，并通过文献复习为后续相似的案例提供用药参考。结果与结论 碳青霉烯类药物联用丙戊酸钠可导致丙戊酸钠血药浓度明显下降，临床可通过调整抗癫痫药物、抗感染药物或加强患者的监测，取得良好的治疗效果。 |
| 关键词: 临床药师 临床实践 美罗培南 丙戊酸钠 |
| DOI：10.13748/j.cnki.issn1007-7693.2016.12.021 |
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| One Case of Clinical Pharmacists Participating in the Clinical Practice of Meropenem Combined with Valproic Acid |
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JIANG Zhengli1,2, ZHANG Huimin2, HU Xiaoming2, YANG Jianmiao2, XU Donghang1,3
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1.Zhejiang University, Hangzhou 310058, China;2.Taizhou Hospital of Zhejiang Province, Linhai 317000, China;3.Second Affiliated Hospital, School of Medicine of Zhejiang University, Hangzhou 310009, China
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| Abstract: |
| OBJECTIVE To provide rational medication reference advice for patients by summaring the clinical practice of clinical pharmacists participating in a case of meropenem combined with valproic acid after craniocerebral operation. METHODS Clinical pharmacists analyzed the case in which there was a combination of meropenem and valproic acid after craniocerebral operation that led to decrease the serum concentration of valproic acid significantly, and proposed the serum concentration monitoring and medication suggestion, then provided medication reference for similar cases as follows through literatures review. RESULTS & CONCLUSION The combination of carbapenems and valproic acid may lead to decrease the serum concentration of valproic acid significantly, clinical pharmacists advised to adjust antiepileptic drugs, anti-infective drugs or strengthen monitoring patients in clinical to obtain the good treatment effect. |
| Key words: clinical pharmacists clinical practice meropenem valproic acid |
