| 引用本文: | 柴奇,刘学娜,郭美辰,韩维娜.苯磺顺阿曲库铵合成工艺的研究进展[J].中国现代应用药学,2017,34(3):475-478. |
| CHAI Qi,LIU Xuena,GUO Meichen,HAN Weina.Research Progress of Methods for Preparing Cisatracurium Besylate[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(3):475-478. |
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| 摘要: |
| 苯磺顺阿曲库铵是经典的非去极化中时效神经肌肉阻断剂，其合成方法受到广泛关注。本文通过查阅1982-2015年文献和专利，分析苯磺顺阿曲库铵的合成过程，对其合成路线和工艺技术进行综述，并讨论了苯磺顺阿曲库铵合成工艺的总收率较低的原因，发现其手性药物拆分后的分离方法有较大的发展前景。 |
| 关键词: 苯磺顺阿曲库铵 R-四氢罂粟碱 同分异构体 合成 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.03.039 |
| 分类号: |
| 基金项目:黑龙江省应用技术研究与开发计划项目（GC13C110） |
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| Research Progress of Methods for Preparing Cisatracurium Besylate |
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CHAI Qi, LIU Xuena, GUO Meichen, HAN Weina
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College of Pharmacy Harbin Medical University, Harbin 150081, China
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| Abstract: |
| Cisatracurium besylate is a classic nondepolarizing neuromuscular blocking agent. Its synthetic methods have been widely concerned. It is analyzed the synthetic process of cisatracurium besylate and summarizes synthetic routes and technology by searching the references and patents from 1982 to 2015, discussing low rate of synthetic routes of cisatracurium besylate. Its separation of chiral drugs have wider development prospect. |
| Key words: cisatracurium besylate R-tetrahydropapaverine isomer synthesis |
